ArticleAsian Pacific journal of cancer prevention : APJCP2021
Spatial Association between Gastric Cancer Mortality and Goiter in Sardinia.
Article in Asian Pacific journal of cancer prevention : APJCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- Curcumin ameliorated low dose-Bisphenol A induced gastric toxicity in adult albino rats.Scientific reports · 2022Article
- Government drivers of breast cancer prevention: A spatiotemporal analysis based on the association between breast cancer and macro factors.Frontiers in public health · 2022Article
- Does the trained immune system play an important role in the extreme longevity that is seen in the Sardinian blue zone?Frontiers in aging · 2022Article
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5 authors at 1 institution in 1 country.
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Abstract
backgroundGastric cancer (GC) is the third leading cause of cancer mortality worldwide. The incidence of GC varies between countries according to exposure to different risk factors. Hypothyroidism has been suggested as a potential GC risk factor. In Sardinia, Italy, the prevalence of endemic goiter is high and GC mortality is unevenly distributed. This ecological study aimed to investigate GC mortality and its relationship with hypothyroidism, adjusting for potential confounders.
methodsThe spatial association between GC mortality and goiter (a proxy of hypothyroidism), diet, stature and pastoralism (a proxy of Helicobacter pylori infection), available at the aggregated level, was modelled in the island's 377 municipalities, separately by sex, using geographically weighted regression (GWR).
resultsThe GC standardized mortality ratio ranged from 0.0 to 10.4 across municipalities. A hotspot of GC mortality was detected in the central mountainous area of Sardinia among males, positively associated with goiter (GWR estimate 0.213 ± 0.122), and the practice of sheep‒rearing (GWR estimate 0.127 ± 0.080), whereas a negative association with the diet score (GWR estimate 0.032 ± 0.034), and null for stature were found. No significant associations were found in females.
conclusionWithin the limitations of ecological studies goiter prevalence was an independent predictor of GC mortality in males.
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