Evidence map›Paper›PMID 33507672›Full record

SynthesisAsian Pacific journal of cancer prevention : APJCP2021

Prognostic Value of Two Polymorphisms, rs1045642 and rs1128503, in ABCB1 Following Taxane-based Chemotherapy: A Meta-Analysis.

Quanyao Chen, Wanlong Lin, Jianhui Yang, Min Lin, Xiuxian Lin, Yiyin Weng, Yao Chen

Open access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Asian Pacific journal of cancer prevention : APJCP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Quanyao ChenWomen and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Wanlong LinWomen and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Jianhui YangWomen and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Min LinWomen and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Xiuxian LinWomen and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Yiyin WengWomen and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Yao ChenWomen and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Children’s Hospital of Fudan University Xiamen Branch · CNXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveGenetic polymorphisms can influence the chemotherapeutic response; however, previous studies have produced conflicting results, and have failed to identify the most relevant polymorphisms for predicting the response to treatment in patients with cancer. The present meta-analysis was conducted to determine the correlation between two polymorphisms (rs1045642 and rs1128503) in ATP-binding cassette transporter B subfamily member 1 (ABCB1), which is associated with multidrug resistance, and the survival of patients treated with taxane-containing chemotherapy.

methodsSeveral databases, including PubMed and Embase, were used to retrieve articles evaluating the association between the ABCB1 rs1045642 and rs1128503 polymorphisms and survival, published prior to August 2019. The meta-analysis was conducted using R software to determine the pooled hazard ratio (HR) and 95% confidence intervals (95% CIs).

resultsFifteen studies involving 3320 patients were included in the meta-analysis. The effect of the rs1128503 polymorphism on progression-free survival remained significant in the heterozygote (HR 0.81; 95% CI: 0.67-0.98) and homozygote (HR 0.71; 95% CI: 0.58-0.88) models. The TT genotype rs1128503 was associated with better overall survival (HR 0.72; 95% CI: 0.53-0.97).

conclusionCarriers of the rs1128503 T allele of ABCB1 showed a survival benefit after taxane-containing chemotherapy.

Indexed as

Polymorphism, Single NucleotideATP Binding Cassette Transporter, Subfamily BBiomarkers, TumorBridged-Ring CompoundsHumansNeoplasmsPrognosisSurvival RateTaxoidsABCB1 protein, humanATP Binding Cassette Transporter, Subfamily BBiomarkers, TumorBridged-Ring CompoundstaxaneTaxoidsABCB1Overall survivalPaclitaxelProgression-free survivaltaxane

Identifiers

PMID33507672
PMCPMC8184199
OpenAlexW3122806760

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.