ArticleJournal of clinical laboratory analysis2021
Correlation between the platelet-to-lymphocyte ratio and diabetic foot ulcer in patients with type 2 diabetes mellitus.
Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between Lipid Profile and Apolipoproteins with Risk of Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis.International journal of clinical practice · 2022Pooled it
- Review
- Association of Inflammatory-Hematological Biomarkers with Hypertension and Related Comorbidities.Journal of clinical medicine · 2026Article
- Development and validation of a diagnostic nomogram for Wagner grade≥2 diabetic foot ulcers in hospitalized patients with type 2 diabetes.Frontiers in endocrinology · 2026Article
- Immune cells in diabetic wound repair: the key to better wound management.Frontiers of medicine · 2025Review
- Review
- Article
- Predictive Factors of Amputation in Diabetic Foot.Biomedicines · 2024Article
- Comparison of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and C-reactive protein in predicting osteomyelitis in patients with diabetic foot ulcer.Journal of diabetes and metabolic disorders · 2024Article
- The impact of inflammatory biomarkers on amputation rates in patients with diabetic foot ulcers.International wound journal · 2024Article
- Correlation between insulin resistance and the rate of neutrophils-lymphocytes, monocytes-lymphocytes, platelets-lymphocytes in type 2 diabetic patients.BMC endocrine disorders · 2024Article
- Platelet-to-lymphocyte ratio and serum hsCRP levels in third trimester and adverse pregnancy outcomes in women with gestational diabetes mellitus.Scientific reports · 2023Article
- Platelet-to-Lymphocyte Ratio Predicts the Presence of Diabetic Neurogenic Bladder.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Research on the correlation of immunity in patients with chronic insomnia.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo investigate the correlation between the platelet-to-lymphocyte ratio (PLR) and diabetic foot ulcer (DFU) in patients with type 2 diabetes mellitus (T2DM).
methodFrom January 2018 to August 2019, 206 patients with T2DM admitted to the Central Hospital of Wuhan, China, were enrolled in this study, including 104 patients with DFU (DFU group) and 102 patients without DFU (T2DM group). During the same period, 90 healthy subjects were randomly screened as normal controls (NC group). The correlation between PLR and DFU in patients with T2DM was explored by comparing the PLR of the subjects in the three groups.
resultsThe PLRs of the DFU and T2DM groups were higher than that of the NC group, whereas the PLR of the DFU group was higher than that of the T2DM group (p < 0.05). PLR was positively correlated with the Wagner DFU grade (p < 0.001). Based on logistic regression analysis, PLR was found to be an independent risk factor for DFU (OR =1.029, 95% CI: 1.019 ~ 1.039, p < 0.001). The receiver operating characteristic curve analysis of the PLR showed that the area under the curve of the PLR for predicting diabetic foot ulcer was 0.776 (p < 0.001), and the analysis determined that the optimal critical value of the PLR for predicting DFU was 147.6.
conclusionThe PLR is significantly elevated in patients with DFU and positively correlated with the Wagner DFU grade, which might be a valuable marker for early diagnosis and assessment of severity of DFU.
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