Evidence map›Paper›PMID 33507459›Full record

ArticleJournal of autism and developmental disorders2021

Identifying Subgroups of Toddlers with DSM-5 Autism Spectrum Disorder Based on Core Symptoms.

Holly K Harris, Collin Lee, Georgios D Sideridis, William J Barbaresi, Elizabeth Harstad

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Accuracy of initial diagnostic impressions of autism in toddlers and behaviors that inform these impressions.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Holly K HarrisDivision of Developmental Medicine, Massachusetts and Harvard Medical School, Boston Children's Hospital, Fegan 10, 300 Longwood Avenue, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0001-5512-755X
Collin LeeDivision of Developmental Medicine, Massachusetts and Harvard Medical School, Boston Children's Hospital, Fegan 10, 300 Longwood Avenue, Boston, MA, 02115, USA.
Georgios D SideridisDivision of Developmental Medicine, Massachusetts and Harvard Medical School, Boston Children's Hospital, Fegan 10, 300 Longwood Avenue, Boston, MA, 02115, USA.
William J BarbaresiDivision of Developmental Medicine, Massachusetts and Harvard Medical School, Boston Children's Hospital, Fegan 10, 300 Longwood Avenue, Boston, MA, 02115, USA.
Elizabeth HarstadDivision of Developmental Medicine, Massachusetts and Harvard Medical School, Boston Children's Hospital, Fegan 10, 300 Longwood Avenue, Boston, MA, 02115, USA. Elizabeth.harstad@childrens.harvard.edu.
Boston Children's Hospital · US

Funding

Palmer Family Fund for Autism Research Private Philanthropic Funding
6 · The paper itself

Abstract

The objective of this study was to identify subgroups of toddlers with DSM-5 ASD based on core ASD symptoms using a person-based analytical framework. This is a retrospective study of 500 toddlers (mean age 26 months, 79% male) with DSM-5 ASD. Data were analyzed using latent class analyses in which profiles were formed based on ASD symptomatology. Social communication (SC) symptoms favored a three-class solution, while restricted/repetitive behaviors (RRBs) favored a two-class solution. Classes with higher consistency of SC deficits were younger, with lower developmental functioning. The class with more RRBs was older, with higher functioning. If confirmed in other populations, these classes may more precisely characterize subgroups within the heterogeneous group of toddlers at time of ASD diagnosis.

Indexed as

Autism Spectrum DisorderChild, PreschoolCognitionCommunicationDiagnostic and Statistical Manual of Mental DisordersFemaleHumansMaleRetrospective StudiesAutism spectrum disorderCore symptomsSubgroupsToddlers

Identifiers

PMID33507459
OpenAlexW3124363574

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.