ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2021
Desmoplastic infantile astrocytoma and ganglioglioma: a series of 12 patients treated at a single institution.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A 6-year-old boy with left temporal lobe mass.Brain pathology (Zurich, Switzerland) · 2026Article
- Malignant transformation of desmoplastic infantile tumors in a non-infant: a case report.Frontiers in oncology · 2023Article
- Desmoplastic infantile astrocytoma with atypical phenotype, PTEN homozygous deletion and BRAF V600E mutation.Acta neuropathologica communications · 2022Article
- Desmoplastic infantile ganglioglioma/astrocytoma: Expanding the molecular and morphological spectrum with a novel BRAF fusion.Neuro-oncology advancesArticle
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Abstract
backgroundDesmoplastic infantile astrocytomas and gangliogliomas (DIA/DIG) usually present with a large size, large cystic component, large dural implant, encasement of big vessels, clinical presentation within 18 months of life, high incidence of seizures and overall good prognosis, even if tumour surgery can be very challenging at first procedure.
methodsWe retrospectively reviewed clinical and radiological data of patients diagnosed with desmoplastic infantile tumours who were surgically treated between 2008 and 2019.
resultsThe series included 12 patients. The median age at surgery was 91 days. The average tumour volume was 212 cm
conclusionDesmoplastic infantile tumours are rare giant neonatal tumours. Total removal is the goal of treatment, but prognosis remains good even if total removal is not achieved. In case of tumour progression or epilepsy from residual tumour, reoperation is the first option, with chemotherapy reserved to unresectable or disseminated cases with mixed results, while, to date, radiotherapy still plays no role.
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