Evidence map›Paper›PMID 33507326›Full record

ArticleCellular and molecular life sciences : CMLS2021

Targeted disruption of galectin 3 in mice delays the first wave of spermatogenesis and increases germ cell apoptosis.

Tao Lei, Sandra M Blois, Nancy Freitag, Martin Bergmann, Sudhanshu Bhushan, Eva Wahle, Annie Chi-Chun Huang, Hung-Lin Chen, Michaela F Hartmann, Stefan A Wudy and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Tao LeiDepartment of Anatomy and Cell Biology, Justus-Liebig-University of Giessen, Aulweg 123, 35385, Giessen, Germany.
Sandra M BloisDepartment of Obstetrics and Fetal Medicine, AG Glycoimmunology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.
Nancy FreitagDepartment of Obstetrics and Fetal Medicine, AG Glycoimmunology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.
Martin BergmannInstitute of Veterinary Anatomy, Histology, and Embryology, Justus-Liebig-University of Giessen, Giessen, Germany.
Sudhanshu BhushanDepartment of Anatomy and Cell Biology, Justus-Liebig-University of Giessen, Aulweg 123, 35385, Giessen, Germany.
Eva WahleDepartment of Anatomy and Cell Biology, Justus-Liebig-University of Giessen, Aulweg 123, 35385, Giessen, Germany.
Annie Chi-Chun HuangInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Hung-Lin ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Michaela F HartmannSteroid Research and Mass Spectrometry Unit, Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University of Giessen, Giessen, Germany.
Stefan A WudySteroid Research and Mass Spectrometry Unit, Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University of Giessen, Giessen, Germany.
Fu-Tong LiuInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Andreas MeinhardtDepartment of Anatomy and Cell Biology, Justus-Liebig-University of Giessen, Aulweg 123, 35385, Giessen, Germany.
Monika FijakDepartment of Anatomy and Cell Biology, Justus-Liebig-University of Giessen, Aulweg 123, 35385, Giessen, Germany. monika.fijak@anatomie.med.uni-giessen.de.ORCID http://orcid.org/0000-0002-7384-3872
Justus-Liebig-Universität Gießen · DEInstitute of Biomedical Sciences, Academia Sinica · TWUniversität Hamburg · DEUnion Hospital · CN

Funding

DFG BL1115/2-1Heisenberg Program BL1115/3-1-BL1115/7-1
6 · The paper itself

Abstract

Galectin 3 is a multifunctional lectin implicated in cellular proliferation, differentiation, adhesion, and apoptosis. This lectin is broadly expressed in testicular somatic cells and germ cells, and is upregulated during testicular development. Since the role of galectin 3 in testicular function remains elusive, we aimed to characterize the role of galectin 3 in testicular physiology. We found that galectin 3 transgenic mice (Lgals3

Indexed as

ApoptosisSpermatogenesisAnimalsFollicle Stimulating HormoneGalectin 3Leydig CellsMaleMiceMice, Inbred C57BLMice, KnockoutSertoli CellsSpermatozoaTestosteroneFollicle Stimulating HormoneGalectin 3Lgals3 protein, mouseTestosteroneApoptosisGalectin 3Leydig cellsSertoli cell maturationSpermatogenesisTestis

Identifiers

PMID33507326
PMCPMC11072302
OpenAlexW3125274782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.