Evidence map›Paper›PMID 33507325›Full record

ReviewCellular and molecular life sciences : CMLS2021

The role of micropeptides in biology.

Rui Vitorino, Sofia Guedes, Francisco Amado, Manuel Santos, Nobuyoshi Akimitsu

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. α2-macroglobulin function of thioester-containing proteins guardsProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Mitochondrial Microproteins: Emerging Regulators in Neurodevelopment and Neurodegeneration.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. A micropeptide regulates seed desiccation.Frontiers in plant science · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Current Challenges and Future Directions in Peptidomics.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  19. Review
  20. LncRNAs: Current understanding, future directions, and challenges.Animal models and experimental medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rui VitorinoDepartamento de Cirurgia E Fisiologia, Faculdade de Medicina da Universidade Do Porto, UnIC, Porto, Portugal. rvitorino@ua.pt.ORCID http://orcid.org/0000-0003-3636-5805
Sofia GuedesDepartamento de Química, LAQV-REQUIMTE, Universidade de Aveiro, Aveiro, Portugal.
Francisco AmadoDepartamento de Química, LAQV-REQUIMTE, Universidade de Aveiro, Aveiro, Portugal.
Manuel SantosDepartment of Medical Sciences, iBiMED, University of Aveiro, Aveiro, Portugal.
Nobuyoshi AkimitsuIsotope Science Center, The University of Tokyo, Tokyo, Japan. akimitsu@ric.u-tokyo.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Micropeptides are small polypeptides coded by small open-reading frames. Progress in computational biology and the analyses of large-scale transcriptomes and proteomes have revealed that mammalian genomes produce a large number of transcripts encoding micropeptides. Many of these have been previously annotated as long noncoding RNAs. The role of micropeptides in cellular homeostasis maintenance has been demonstrated. This review discusses different types of micropeptides as well as methods to identify them, such as computational approaches, ribosome profiling, and mass spectrometry.

Indexed as

AnimalsComputational BiologyGenomeHumansOpen Reading FramesPeptidesRibosomesRNA, Long NoncodingPeptidesRNA, Long NoncodingLong noncoding RNAShort ORFsORFuORFUpstream ORF

Identifiers

PMID33507325
PMCPMC11073438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.