Observational studyEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2022
A nationwide observational cohort study of the relationship between beta-blockade and survival after hip fracture surgery.
Observational study in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Prognostic value of the red cell distribution width to albumin ratio in predicting mortality in elderly hip fracture patients undergoing hemiarthroplasty.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Observational
- Predictors of 1-year mortality in a clinical cohort of hip fracture patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Influence of a chronic beta-blocker therapy on perioperative opioid consumption - a post hoc secondary analysis.BMC anesthesiology · 2024Article
- Investigating the link between frailty and outcomes in geriatric patients with isolated rib fractures.Trauma surgery & acute care open · 2024Article
- A nationwide analysis on the interaction between frailty and beta-blocker therapy in hip fracture patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- The mortality burden of frailty in hip fracture patients: a nationwide retrospective study of cause-specific mortality.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- Mortality risk stratification in isolated severe traumatic brain injury using the revised cardiac risk index.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Dementia is a surrogate for frailty in hip fracture mortality prediction.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Focus on geriatric proximal femur fractures: factors that influence the outcome.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Mode of anesthesia is not associated with outcomes following emergency hip fracture surgery: a population-level cohort study.Trauma surgery & acute care open · 2022Article
- The interaction between pre-admission β-blocker therapy, the Revised Cardiac Risk Index, and mortality in geriatric hip fracture patients.The journal of trauma and acute care surgery · 2022Article
- Beta-Blocker Therapy Is Associated With Increased 1-Year Survival After Hip Fracture Surgery: A Retrospective Cohort Study.Anesthesia and analgesia · 2021Observational
- Predicting 1-Year Mortality after Hip Fracture Surgery: An Evaluation of Multiple Machine Learning Approaches.Journal of personalized medicine · 2021Article
- Admission Resting Heart Rate as an Independent Predictor of All-Cause Mortality in Elderly Patients with Hip Fracture.International journal of general medicine · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDespite advances in the care of hip fractures, this area of surgery is associated with high postoperative mortality. Downregulating circulating catecholamines, released as a response to traumatic injury and surgical trauma, is believed to reduce the risk of death in noncardiac surgical patients. This effect has not been studied in hip fractures. This study aims to assess whether survival benefits are gained by reducing the effects of the hyper-adrenergic state with beta-blocker therapy in patients undergoing emergency hip fracture surgery.
methodsThis is a retrospective nationwide observational cohort study. All adults [Formula: see text] 18 years were identified from the prospectively collected national quality register for hip fractures in Sweden during a 10-year period. Pathological fractures were excluded. The cohort was subdivided into beta-blocker users and non-users. Poisson regression with robust standard errors and adjustments for confounders was used to evaluate 30-day mortality.
results134,915 patients were included of whom 38.9% had ongoing beta-blocker therapy at the time of surgery. Beta-blocker users were significantly older and less fit for surgery. Crude 30-day all-cause mortality was significantly increased in non-users (10.0% versus 3.7%, p < 0.001). Beta-blocker therapy resulted in a 72% relative risk reduction in 30-day all-cause mortality (incidence rate ratio 0.28, 95% CI 0.26-0.29, p < 0.001) and was independently associated with a reduction in deaths of cardiovascular, respiratory, and cerebrovascular origin and deaths due to sepsis or multiorgan failure.
conclusionsBeta-blockers are associated with significant survival benefits when undergoing emergency hip fracture surgery. Outlined results strongly encourage an interventional design to validate the observed relationship.
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