Evidence map›Paper›PMID 33507312›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2021

Regulation of Toll-like receptor-mediated inflammatory response by microRNA-152-3p-mediated demethylation of MyD88 in systemic lupus erythematosus.

Bei Tao, Wei Xiang, Xianglong Li, Chengsong He, Ligang Chen, Xiangguo Xia, Tangming Peng, Lilei Peng, Xiaobo Yang, Chuanhong Zhong

Abstract read
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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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  4. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
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  12. Serum miRNA modulations indicate changes in retinal morphology.Frontiers in molecular neuroscience · 2023
    Article
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  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Bei Tao *Department of Rheumatology and Immunology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, People's Republic of China.
Wei Xiang *Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Luzhou, 646000, Sichuan Province, People's Republic of China.
Xianglong LiDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Luzhou, 646000, Sichuan Province, People's Republic of China.
Chengsong HeDepartment of Rheumatology and Immunology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, People's Republic of China.
Ligang ChenDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Luzhou, 646000, Sichuan Province, People's Republic of China.
Xiangguo XiaDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Luzhou, 646000, Sichuan Province, People's Republic of China.
Tangming PengDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Luzhou, 646000, Sichuan Province, People's Republic of China.
Lilei PengDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Luzhou, 646000, Sichuan Province, People's Republic of China.
Xiaobo YangDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Luzhou, 646000, Sichuan Province, People's Republic of China.
Chuanhong ZhongDepartment of Neurosurgery, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Luzhou, 646000, Sichuan Province, People's Republic of China. neurosurgery@swmu.edu.cn.ORCID http://orcid.org/0000-0003-0699-1012
Affiliated Hospital of Southwest Medical University · CNSouthwest Medical University · CN

Funding

Project Program of Neurosurgical Clinical Research Center of Sichuan Province, Science and Technology Foundation of Luzhou 2015-S-45(2/5)Science and Technology Foundation of Southwest Medical University 2017-ZRQN-110Science and Technology Foundation of Southwest Medical University 2017-ZRQN-180
6 · The paper itself

Abstract

objectivemicroRNAs (miRNAs) play critical roles in embryogenesis, cell differentiation and the pathogenesis of several human diseases, including systemic lupus erythematosus (SLE). Toll-like receptors (TLRs) are also known to exert crucial functions in the immune response activation occurring in the pathogenesis of autoimmune diseases like SLE. Herein, the current study aimed to explore the potential role of miR-152-3p in TLR-mediated inflammatory response in SLE.

methodsWe determined the miR-152-3p expression profiles in CD4

resultsThe obtained findings revealed that miR-152-3p was highly-expressed in CD4

conclusionOur study suggests that miR-152-3p promotes TLR-mediated inflammatory response in CD4

Indexed as

MicroRNAsAdolescentAdultAgedAnimalsAntibodies, Anti-IdiotypicAntibodies, AntinuclearArthralgiaChildCytokinesDemethylationDNA (Cytosine-5-)-Methyltransferase 1ErythemaFaceFemaleHumansAntibodies, Anti-IdiotypicAntibodies, Antinuclearanti-dsDNA autoantibodyanti-IgGCytokinesDNA (Cytosine-5-)-Methyltransferase 1DNMT1 protein, humanMicroRNAsMIRN152 microRNA, humanMYD88 protein, humanMyeloid Differentiation Factor 88Toll-Like ReceptorsCD4+ T cellsDNA methyltransferase 1Inflammatory responsemicroRNA-152-3pMyeloid differentiation primary response gene 88Systemic lupus erythematosusToll-like receptor

Identifiers

PMID33507312
OpenAlexW3122474442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.