Evidence map›Paper›PMID 33506796›Full record

ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2021

European position paper on the management of patients with patent foramen ovale. Part II - Decompression sickness, migraine, arterial deoxygenation syndromes and select high-risk clinical conditions.

Christian Pristipino, Peter Germonpré, Danilo Toni, Horst Sievert, Bernhard Meier, Fabrizio D'Ascenzo, Sergio Berti, Eustaquio Maria Onorato, Francesco Bedogni, Jean-Louis Mas and 11 more

Open access · hybridAbstract readConsensus Statement
In one paragraph

Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Experimental Study of the TAI QINGActa Cardiologica Sinica · 2025
    Article
  3. Article
  4. Article
  5. [A case report of benign paroxysmal vertigo of childhood complicated with patent foramen ovale and emotional disorder].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  6. Treatment of patent foramen ovale.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025
    Review
  7. Article
  8. Article
  9. Patent Foramen Ovale (PFO): History, Diagnosis, and Management.Reviews in cardiovascular medicine · 2024
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Nickel Hypersensitivity to Atrial Septal Occluders: Smoke Without Fire?Clinical reviews in allergy & immunology · 2022
    Review
  19. A systematic transoesophageal echocardiography study of suture-mediated percutaneous patent foramen ovale closure.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 17 institutions in 10 countries.

Christian PristipinoS. Filippo Neri Hospital ASL Roma 1, Rome, Italy.
Peter Germonpré
Danilo Toni
Horst Sievert
Bernhard Meier
Fabrizio D'Ascenzo
Sergio Berti
Eustaquio Maria Onorato
Francesco Bedogni
Jean-Louis Mas
Paolo Scacciatella
David Hildick-Smith
Fiorenzo Gaita
Paul A Kyrle
John Thomson
Geneviève Derumeaux
Dirk Sibbing
Massimo Chessa
Marius Hornung
Jose Zamorano
Dariusz Dudek
IRCCS Policlinico San Donato · ITUniversity of Turin · ITASL Roma · ITCardiovascular Center Frankfurt · DECentro Cardiologico Monzino · ITDélégation Paris 5 · FRInstituto Cajal · ESJagiellonian University · PLLeeds General Infirmary · GBLudwig-Maximilians-Universität München · DEMedical University of Vienna · ATPoliclinico Umberto I · ITQueen Astrid Military Hospital · BESussex County Community College · USUniversité Paris-Est Créteil · FRUniversity Hospital of Bern · CHUniversity of California, San Francisco · US

Funding

British Heart Foundation CS/15/7/31679
6 · The paper itself

Abstract

Patent foramen ovale (PFO) is implicated in the pathogenesis of a number of medical conditions but to date only one official position paper related to left circulation thromboembolism has been published. This interdisciplinary paper, prepared with the involvement of eight European scientific societies, reviews the available evidence and proposes a rationale for decision making for other PFO-related clinical conditions. In order to guarantee a strict evidence-based process, we used a modified grading of recommendations, assessment, development, and evaluation (GRADE) methodology. A critical qualitative and quantitative evaluation of diagnostic and therapeutic procedures was performed, including assessment of the risk/benefit ratio. The level of evidence and the strength of the position statements were weighed and graded according to predefined scales. Despite being based on limited and observational or low-certainty randomised data, a number of position statements were made to frame PFO management in different clinical settings, along with suggestions for new research avenues. This interdisciplinary position paper, recognising the low or very low certainty of existing evidence, provides the first approach to several PFO-related clinical scenarios beyond left circulation thromboembolism and strongly stresses the need for fresh high-quality evidence on these topics.

Indexed as

Decompression SicknessForamen Ovale, PatentMigraine DisordersHumansRisk AssessmentSyndrome

Identifiers

PMID33506796
PMCPMC9724983
OpenAlexW3124638093

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.