Evidence map›Paper›PMID 33506764›Full record

ArticleThe Annals of thoracic surgery2021

Clinical Outcomes of Lung Transplants From Donors With Unexpected Pulmonary Embolism.

Yuriko Terada, Jason M Gauthier, Michael K Pasque, Tsuyoshi Takahashi, Jingxia Liu, Ruben G Nava, Ramsey R Hachem, Chad A Witt, Derek E Byers, Rodrigo Vazquez Guillamet and 7 more

Open access · greenAbstract read
In one paragraph

Article in The Annals of thoracic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Observational
  2. Article
  3. Venous thromboembolism following lung transplantation.World journal of transplantation · 2025
    Review
  4. Article
  5. Pulmonary Embolism in Donor Lungs-Incidence and Management.The International journal of angiology : official publication of the International College of Angiology, Inc · 2024
    Review
  6. Pulmonary Embolism Following Lung Transplantation: Prevention and Management.The International journal of angiology : official publication of the International College of Angiology, Inc · 2024
    Review
  7. Lungs From Donors ≥70 Years of Age for Transplantation-Do Long-Term Outcomes Justify Their Use?Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Yuriko TeradaDivision of Cardiothoracic Surgery, Department of Surgery, Washington University, Saint Louis, Missouri.
Jason M GauthierDivision of Cardiothoracic Surgery, Department of Surgery, Washington University, Saint Louis, Missouri.
Michael K PasqueDivision of Cardiothoracic Surgery, Department of Surgery, Washington University, Saint Louis, Missouri.
Tsuyoshi TakahashiDivision of Cardiothoracic Surgery, Department of Surgery, Washington University, Saint Louis, Missouri.
Jingxia LiuDivision of Public Health Sciences, Department of Surgery, Washington University, Saint Louis, Missouri.
Ruben G NavaDivision of Cardiothoracic Surgery, Department of Surgery, Washington University, Saint Louis, Missouri.
Ramsey R HachemDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University, Saint Louis, Missouri.
Chad A WittDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University, Saint Louis, Missouri.
Derek E ByersDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University, Saint Louis, Missouri.
Rodrigo Vazquez GuillametDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University, Saint Louis, Missouri.
Benjamin D KozowerDivision of Cardiothoracic Surgery, Department of Surgery, Washington University, Saint Louis, Missouri.
Bryan F MeyersDivision of Cardiothoracic Surgery, Department of Surgery, Washington University, Saint Louis, Missouri.
Patrick R AguilarDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University, Saint Louis, Missouri.
Hrishikesh S KulkarniDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University, Saint Louis, Missouri.
G Alexander PattersonDivision of Cardiothoracic Surgery, Department of Surgery, Washington University, Saint Louis, Missouri.
Daniel KreiselDivision of Cardiothoracic Surgery, Department of Surgery, Washington University, Saint Louis, Missouri; Department of Pathology and Immunology, Washington University, Saint Louis, Missouri.
Varun PuriDivision of Cardiothoracic Surgery, Department of Surgery, Washington University, Saint Louis, Missouri. Electronic address: varunpuri@wustl.edu.
Washington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Optimizing Donor Management in Lung TransplantationR01HL146856 · NHLBI · WASHINGTON UNIVERSITY · PI Ana Baumann Walker, Matthew Galen Hartwig · 2020 to 2026
$2.7M
NCI NIH HHS P30 CA091842NHLBI NIH HHS R01 HL146856
6 · The paper itself

Abstract

backgroundPulmonary embolism (PE) is unexpectedly detected in some donor lungs during organ procurement for lung transplantation. Anecdotally, such lungs are usually implanted; however, the impact of this finding on recipient outcomes remains unclear. We hypothesized that incidentally detected donor PE is associated with adverse short-term and long-term outcomes among lung transplant recipients.

methodsWe analyzed a prospectively maintained database of all lung donors procured by a single surgeon and transplanted at our institution between 2009 and 2018. A standardized approach was used for all procurements and included antegrade and retrograde flush. Pulmonary embolism was defined as macroscopic thrombus seen in the pulmonary artery during the donor procurement operation.

resultsA total of 501 consecutive lung procurements were performed during the study period. The incidence of donor PE was 4.4% (22 of 501). No organs were discarded owing to PE. Donors with PE were similar to donors without PE in baseline characteristics and Pao

conclusionsLungs from donors with incidentally detected PE may be associated with a higher incidence of recipient acute cellular rejection as well as reduced chronic lung allograft dysfunction-free survival. Surgeons must use caution when transplanting lungs with incidentally discovered PE. These preliminary findings warrant corroboration in larger data sets.

Indexed as

Tissue DonorsTransplant RecipientsAdultFemaleFollow-Up StudiesGraft RejectionHumansIncidenceLung TransplantationMaleMiddle AgedPulmonary EmbolismRetrospective StudiesRisk FactorsTissue and Organ ProcurementUnited States

Identifiers

PMID33506764
PMCPMC8060353
OpenAlexW3093893160

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.