ArticleAdvanced healthcare materials2021
Biomimetic Tympanic Membrane Replacement Made by Melt Electrowriting.
Article in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- From Fiber Architecture to Functional Attachment: A Clinically Relevant, Mechanically Tunable Cardiac Patch.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Fibrous Biomaterial Scaffold for Tympanic Membrane Repair: Microarchitectural Engineering and Structure Function Performance.Journal of functional biomaterials · 2026Review
- Topology-optimized melt-electrowritten PCL patch for abdominal wall reconstruction.Bioactive materials · 2026Article
- Review
- Tunable ciprofloxacin delivery through personalized electrospun patches for tympanic membrane perforations.Bioactive materials · 2024Article
- Melt-electrowriting-enabled anisotropic scaffolds loaded with valve interstitial cells for heart valve tissue Engineering.Journal of nanobiotechnology · 2024Article
- Piezoelectric Multi-Channel Bilayer Transducer for Sensing and Filtering Ossicular Vibration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Three-Dimensional-Printed GelMA-KerMA Composite Patches as an Innovative Platform for Potential Tissue Engineering of Tympanic Membrane Perforations.Nanomaterials (Basel, Switzerland) · 2024Article
- Polyacrylamide/Gel-Based Self-Healing Artificial Tympanic Membrane for Drug Delivery of Otitis Treatment.Biomaterials research · 2024Article
- Article
- 3D printing of bio-instructive materials: Toward directing the cell.Bioactive materials · 2023Article
- Melt Electrowriting of Graded Porous Scaffolds to Mimic the Matrix Structure of the Human Trabecular Meshwork.ACS biomaterials science & engineering · 2022Article
- 3D Plotting of Calcium Phosphate Cement and Melt Electrowriting of Polycaprolactone Microfibers in One Scaffold: A Hybrid Additive Manufacturing Process.Journal of functional biomaterials · 2022Article
- Mimicking the Human Tympanic Membrane: The Significance of Scaffold Geometry.Advanced healthcare materials · 2021Article
- Biomimetic Tympanic Membrane Replacement Made by Melt Electrowriting.Advanced healthcare materials · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tympanic membrane (TM) transfers sound waves from the air into mechanical motion for the ossicular chain. This requires a high sensitivity to small dynamic pressure changes and resistance to large quasi-static pressure differences. The TM achieves this by providing a layered structure of about 100µm in thickness, a low flexural stiffness, and a high tensile strength. Chronically infected middle ears require reconstruction of a large area of the TM. However, current clinical treatment can cause a reduction in hearing. With the novel additive manufacturing technique of melt electrowriting (MEW), it is for the first time possible to fabricate highly organized and biodegradable membranes within the dimensions of the TM. Scaffold designs of various fiber composition are analyzed mechanically and acoustically. It can be demonstrated that by customizing fiber orientation, fiber diameter, and number of layers the desired properties of the TM can be met. An applied thin collagen layer seals the micropores of the MEW-printed membrane while keeping the favorable mechanical and acoustical characteristics. The determined properties are beneficial for implantation, closely match those of the human TM, and support the growth of a neo-epithelial layer. This proves the possibilities to create a biomimimetic TM replacement using MEW.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.