Evidence map›Paper›PMID 33506542›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2021

Unprecedented Fluorophore Photostability Enabled by Low-Loss Organic Hyperbolic Materials.

Yeon Ui Lee, Shilong Li, Steven Edward Bopp, Junxiang Zhao, Zhaoyu Nie, Clara Posner, Sui Yang, Xiang Zhang, Jin Zhang, Zhaowei Liu

Open access · greenAbstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Hyperbolic polariton-coupled emission optical microscopy.Nanophotonics (Berlin, Germany) · 2025
    Article
  2. Metamaterial-Assisted Illumination Nanoscopy with Exceptional Axial Resolution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  3. Article
  4. Roadmap on Label-Free Super-Resolution Imaging.Laser & photonics reviews · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Organic Hyperbolic Material Assisted Illumination Nanoscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yeon Ui LeeDepartment of Electrical and Computer Engineering, University of California, San Diego, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID https://orcid.org/0000-0001-8857-1251
Shilong LiDepartment of Electrical and Computer Engineering, University of California, San Diego, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Steven Edward BoppMaterials Science and Engineering, University of California, San Diego, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Junxiang ZhaoDepartment of Electrical and Computer Engineering, University of California, San Diego, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Zhaoyu NieDepartment of Mechanical Engineering, University of California, Berkele, Berkeley, CA, 94720, USA.
Clara PosnerDepartment of Pharmacology, University of California, San Dieg, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Sui YangDepartment of Mechanical Engineering, University of California, Berkele, Berkeley, CA, 94720, USA.
Xiang ZhangDepartment of Mechanical Engineering, University of California, Berkele, Berkeley, CA, 94720, USA.
Jin ZhangDepartment of Pharmacology, University of California, San Dieg, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Zhaowei LiuDepartment of Electrical and Computer Engineering, University of California, San Diego, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
University of California San Diego · USUniversity of California, Berkeley · US

Funding

Live-cell Activity Architecture in CancerR35CA197622 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jin Zhang · 2015 to 2026
$11.2M
Basic Energy Sciences DE-AC02-05CH11231NCI NIH HHS R35 CA197622Office of ScienceU.S. Department of Energy DE-AC02-05CH11231
6 · The paper itself

Abstract

The dynamics of photons in fluorescent molecules plays a key role in fluorescence imaging, optical sensing, organic photovoltaics, and displays. Photobleaching is an irreversible photodegradation process of fluorophores, representing a fundamental limitation in relevant optical applications. Chemical reagents are used to suppress the photobleaching rate but with exceptionally high specificity for each type of fluorophore. Here, using organic hyperbolic materials (OHMs), an optical platform to achieve unprecedented fluorophore photostability without any chemical specificity is demonstrated. A more than 500-fold lengthening of the photobleaching lifetime and a 230-fold increase in the total emitted photon counts are observed simultaneously. These exceptional improvements solely come from the low-loss hyperbolic dispersion of OHM films and the large resultant Purcell effect in the visible spectral range. The demonstrated OHM platform may open up a new paradigm in nanophotonics and organic plasmonics for super-resolution imaging and the engineering of light-matter interactions at the nanoscale.

Indexed as

natural hyperbolic materialsorganic hyperbolic materialsphotostabilitypoly(3-hexylthiophenes)Purcell effect

Identifiers

PMID33506542
PMCPMC8783542
OpenAlexW3123568480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.