Evidence map›Paper›PMID 33506540›Full record

ArticleInternational journal of cancer2021

Bladder cancer risk associated with family history of cancer.

Stella Koutros, Kathy L Decker, Dalsu Baris, Larissa A Pardo, Alison Johnson, G M Monawar Hosain, Nathaniel Rothman, Margaret R Karagas, Molly R Schwenn, Debra T Silverman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Stella KoutrosOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0001-5294-5485
Kathy L DeckerUniversity of Southern Maine, Muskie School of Public Service, Cutler Institute, Augusta, Maine, USA.
Dalsu BarisFormerly of the Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Larissa A PardoFormerly of the Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Alison JohnsonDivision of Health Surveillance, Vermont Cancer Registry, Burlington, Vermont, USA.
G M Monawar HosainFormerly of the Bureau of Public Health Statistics and Informatics, Department of Health and Human Services, Concord, New Hampshire, USA.
Nathaniel RothmanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Molly R SchwennFormerly of the Maine Department of Health and Human Services, Maine Cancer Registry, Augusta, Maine, USA.
Debra T SilvermanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
National Institutes of Health · USState of Maine Department of Health and Human Services · USDartmouth College · USUnited States Department of Health and Human Services · USVermont Department of Health · US

Funding

Cancer Risk and Environmental ExposuresZIACP010125 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI PURDUE, MARK · 2009 to 2025
$41.3M
INVESTIGATIONS OF ENVIRONMENTAL EXPOSURES AND CANCERZ01CP010125 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI CANTOR, KENNETH · 1996 to 2008
$108k
Intramural NIH HHS Z01 CP010125Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA CP010125NCI NIH HHS ZIA CP010125-24
6 · The paper itself

Abstract

Twin studies suggest a familial aggregation of bladder cancer, but elements of this increased familial risk of bladder cancer are not well understood. To characterize familial risk of bladder cancer, we examined the relationship between family history of bladder and other types of cancer among first-degree relatives and risk of bladder cancer in 1193 bladder cancer cases and 1418 controls in a large population-based case-control study. Multivariate logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between family history of bladder cancer (defined as at least one first-degree family member with bladder cancer or a cancer of any other site). We also evaluated cancer aggregation of specific sites in family members. Participants with a first-degree relative with bladder cancer had nearly double the risk of bladder cancer (OR = 1.8, 95% CI 1.2-2.9) as those without a family history of bladder cancer. Risk was increased for having a sibling with bladder cancer (OR = 2.6, 95% CI 1.3-5.3) compared to no siblings with cancer. Bladder cancer risk was elevated when participants reported a first-degree relative with a history of female genital cancer (OR = 1.5, 95% CI 1.1-2.1), melanoma (OR = 1.9, 95% CI 1.02-3.6), and tobacco-associated cancer (OR = 1.3, 95% CI 1.06-1.6). These findings add to evidence of a familial predisposition to bladder cancer. Clarification of the aggregation of bladder cancer in families and with other cancer sites will be of interest as many loci and common polymorphisms related to bladder cancer have yet to be identified in large genomic studies.

Indexed as

AdultAgedCase-Control StudiesFemaleGenital Neoplasms, FemaleHumansMaineMaleMelanomaMiddle AgedNew HampshirePedigreeRisk AssessmentSmokingTwin Studies as TopicUrinary Bladder Neoplasmsbladder cancerfamilial cancerfamily history

Identifiers

PMID33506540
PMCPMC10294142
OpenAlexW3125867993

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.