Evidence map›Paper›PMID 33506304›Full record

ArticlePsychopharmacology2021

APOE genotype influences P3b amplitude and response to smoking abstinence in young adults.

Ryan Coppens, Norka E Rabinovich, Raghuveer Kanneganti, Herman A Diggs, Kristin Wiggs, Travis Healey, Jodi Huggenvik, Gregory M Rose, David G Gilbert

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. The physiological effects of APOE genotype in healthy young/middle-aged individuals.Biological reviews of the Cambridge Philosophical Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ryan CoppensDepartment of Psychology, Southern Illinois University, Carbondale, IL, USA.
Norka E RabinovichDepartment of Psychology, Southern Illinois University, Carbondale, IL, USA.
Raghuveer KannegantiDepartment of Psychology, Southern Illinois University, Carbondale, IL, USA.
Herman A DiggsDepartment of Psychology, Southern Illinois University, Carbondale, IL, USA.
Kristin WiggsDepartment of Psychology, Southern Illinois University, Carbondale, IL, USA.
Travis HealeyDepartment of Physiology, Southern Illinois University School of Medicine, Springfield, IL, USA.
Jodi HuggenvikDepartment of Physiology, Southern Illinois University School of Medicine, Springfield, IL, USA.
Gregory M RoseCenter for Integrated Research in Cognitive & Neural Sciences, Southern Illinois University, Carbondale, IL, USA.
David G GilbertDepartment of Psychology, Southern Illinois University, Carbondale, IL, USA. dgilbert@siu.edu.ORCID http://orcid.org/0000-0001-7525-7239
Southern Illinois University Carbondale · USSouthern Illinois University School of Medicine · US

Funding

Nicotine for Marijuana WithdrawalR01DA031006 · NIDA · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI GILBERT, DAVID G · 2010 to 2012
$1.0M
Nicotine: Cognition-Affect InteractionsR01DA014104 · NIDA · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI GILBERT, DAVID G · 2003 to 2005
$809k
NIDA NIH HHS R01 DA014104NIDA NIH HHS R01DA31006
6 · The paper itself

Abstract

rationaleThere is strong evidence that nicotine can enhance cognitive functions and growing evidence that this effect may be larger in young healthy APOE ε4 carriers. However, the moderating effects of the APOE ε4 allele on cognitive impairments caused by nicotine deprivation in chronic smokers have not yet been studied with brain indices.

objectiveWe sought to determine whether young female carriers of the APOE ε4 allele, relative to noncarriers, would exhibit larger abstinence-induced decreases in P3b amplitude during a two-stimulus auditory oddball task.

methodsWe compared parietal P3bs in female chronic smokers with either APOE ε3/ε3 (n = 54) or ε3/ε4 (n = 20) genotype under nicotine-sated conditions and after 12-17-h nicotine deprivation.

resultsNicotine deprivation significantly reduced P3b amplitudes in APOE ε4 carriers, but not in APOE-ε3/ε3 individuals, such that the difference seen prior to nicotine deprivation was eliminated.

conclusionsThe results suggest that subjects with the APOE ε4 allele are more sensitive to nicotine, which could influence smoking patterns, the risk for nicotine dependence, and the cognitive effects of nicotine use in these individuals.

Indexed as

Acoustic StimulationAdultApolipoprotein E3ElectroencephalographyFemaleGenotypeHeterozygoteHumansMaleNicotineNicotinic AgonistsParietal LobePsychomotor PerformanceSmokingSmoking CessationYoung AdultApolipoprotein E3NicotineNicotinic AgonistsAPOEAPOE ε4GenotypeNicotineOddball taskP3bSmoking withdrawal

Identifiers

PMID33506304
OpenAlexW3124905562

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.