Evidence map›Paper›PMID 33506059›Full record

Observational studyJournal of immunology research2021

The Gut Microbiota and Its Relevance to Peripheral Lymphocyte Subpopulations and Cytokines in Patients with Rheumatoid Arthritis.

Yuan Li, Sheng-Xiao Zhang, Xu-Fang Yin, Ming-Xing Zhang, Jun Qiao, Xiao-Hong Xin, Min-Jing Chang, Chong Gao, Ya-Feng Li, Xiao-Feng Li

Abstract readObservational Study
In one paragraph

Observational study in Journal of immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

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  5. Recent advances in the positive role ofFrontiers in immunology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuan LiDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, China.
Sheng-Xiao ZhangDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, China.
Xu-Fang YinDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, China.
Ming-Xing ZhangDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, China.
Jun QiaoDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, China.
Xiao-Hong XinDepartment of Nephrology, Precision Medicine Center, The Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China.
Min-Jing ChangDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, China.
Chong GaoDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ya-Feng LiDepartment of Nephrology, Precision Medicine Center, The Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China.ORCID https://orcid.org/0000-0002-7500-0959
Xiao-Feng LiDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, China.ORCID https://orcid.org/0000-0002-8899-1886

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growing experimental and clinical evidence suggests that a chronic inflammatory response induced by gut microbiome critically contribute to the development of rheumatoid arthritis (RA). Previous studies demonstrated the disturbance of lymphocyte subpopulations in RA patients. The purpose of this study was to explore the characteristics of gut microbiome and the associations between bacterium and lymphocyte subpopulations as well as cytokines in patients with RA. Fecal samples from 205 RA patients and 199 healthy controls (HCs) were collected for bacterial DNA extraction and 16S ribosomal RNA (rRNA) gene sequencing. The levels of peripheral lymphocyte subpopulation such as T, B, CD4

Indexed as

AdultArthritis, RheumatoidCase-Control StudiesCytokinesFecesFemaleGastrointestinal MicrobiomeHumansLymphocyte SubsetsMaleMiddle AgedCytokines

Identifiers

PMID33506059
PMCPMC7810541

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.