Evidence map›Paper›PMID 33506058›Full record

ArticleJournal of immunology research2021

Identification of Immune-Related Prognostic Biomarkers Associated with HPV-Positive Head and Neck Squamous Cell Carcinoma.

Yifei Chen, Jin Nie, Xiangsheng Li, Tao Fan, Xiaowen Deng, Dan Liang, Guilin Song

Open access · goldAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yifei ChenDepartment of Otolaryngology Head and Neck Surgery, Affiliated Changsha Hospital of Hunan Normal University, 70 Lushan Road, Changsha, Hunan 410013, China.ORCID https://orcid.org/0000-0002-0943-3369
Jin NieDepartment of Otolaryngology Head and Neck Surgery, Affiliated Changsha Hospital of Hunan Normal University, 70 Lushan Road, Changsha, Hunan 410013, China.ORCID https://orcid.org/0000-0003-2143-525X
Xiangsheng LiDepartment of Otolaryngology Head and Neck Surgery, Affiliated Changsha Hospital of Hunan Normal University, 70 Lushan Road, Changsha, Hunan 410013, China.ORCID https://orcid.org/0000-0003-4228-8316
Tao FanDepartment of Otolaryngology Head and Neck Surgery, Affiliated Changsha Hospital of Hunan Normal University, 70 Lushan Road, Changsha, Hunan 410013, China.ORCID https://orcid.org/0000-0002-2057-4322
Xiaowen DengDepartment of Otolaryngology Head and Neck Surgery, Affiliated Changsha Hospital of Hunan Normal University, 70 Lushan Road, Changsha, Hunan 410013, China.ORCID https://orcid.org/0000-0003-2610-4177
Dan LiangDepartment of Otolaryngology Head and Neck Surgery, Affiliated Changsha Hospital of Hunan Normal University, 70 Lushan Road, Changsha, Hunan 410013, China.ORCID https://orcid.org/0000-0002-6294-5881
Guilin SongDepartment of Otolaryngology Head and Neck Surgery, Affiliated Changsha Hospital of Hunan Normal University, 70 Lushan Road, Changsha, Hunan 410013, China.ORCID https://orcid.org/0000-0001-6683-0777
Hunan Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs a type of malignant tumor, head and neck squamous cell carcinoma (HNSCC) seriously threatens human health. This study is aimed at constructing a new, reliable prognostic model.

methodThe gene expression profile data of HNSCC patients were downloaded from the Gene Expression Omnibus and The Cancer Genome Atlas databases. The immune-related differentially expressed genes (IRDEGs) related to HNSCC were identified. We then used Cox regression analysis and least absolute shrinkage and selection operator (LASSO) analysis to explore IRDEGs related to the HNSCC prognosis and to construct and validate a risk scoring model and used ESTIMATE to evaluate tumor immune infiltration in HNSCC patients. Finally, we validated IGSF5 expression and function in HNSCC cells.

resultsA total of 1,195 IRDEGs were found from the GSE65858 dataset. Thirty-one of the 1,195 IRDEGs were associated with the prognosis of HNSCC. Nine key IRDEGs were further selected using the LASSO method, and a risk scoring model was established for predicting the survival of HNSCC patients. According to the risk scoring model, the prognosis of patients in the high-risk group was worse than that of the low-risk group; the high-risk group had significantly higher immune scores than the low-risk group; and between the high- and low-risk samples, there were significant differences in the proportion of 10 types of cells, including naive cells, plasma cells, and resting CD4

conclusionThis prognostic risk assessment model can help systematically evaluate the survival prognosis of HNSCC patients and provides a new research direction for the improvement of the survival prognosis of HNSCC patients in clinical practice.

Indexed as

Biomarkers, TumorCell Line, TumorDatasets as TopicFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHead and Neck NeoplasmsHumansKaplan-Meier EstimateMaleMiddle AgedModels, GeneticPapillomavirus InfectionsPrognosisRisk AssessmentBiomarkers, Tumor

Identifiers

PMID33506058
PMCPMC7810542
OpenAlexW3119588209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.