Evidence map›Paper›PMID 33506039›Full record

SynthesisBioMed research international2021

Growth Factors in Oral Tissue Engineering: New Perspectives and Current Therapeutic Options.

Luca Fiorillo, Gabriele Cervino, Pablo Galindo-Moreno, Alan Scott Herford, Gianrico Spagnuolo, Marco Cicciù

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

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  6. Applications of Growth Factors in Implant Dentistry.Current issues in molecular biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Luca FiorilloDepartment of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, Policlinico G. Martino, Via Consolare Valeria, 98100 Me, Italy.ORCID https://orcid.org/0000-0003-0335-4165
Gabriele CervinoDepartment of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, Policlinico G. Martino, Via Consolare Valeria, 98100 Me, Italy.
Pablo Galindo-MorenoOral Surgery and Implant Dentistry Department, School of Dentistry, University of Granada, Granada, Spain.
Alan Scott HerfordDepartment of Maxillofacial Surgery, Loma Linda University, Loma Linda, CA 92354, USA.
Gianrico SpagnuoloI. M. Sechenov First Moscow State Medical University, Institute of Dentistry, Moscow, Russia.ORCID https://orcid.org/0000-0003-3769-9786
Marco CicciùDepartment of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, Policlinico G. Martino, Via Consolare Valeria, 98100 Me, Italy.ORCID https://orcid.org/0000-0001-7058-4126
University of Messina · ITLoma Linda University · USSechenov University · RUUniversidad de Granada · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present investigation is aimed at systematically analyzing the recent literature about the innovative scaffold involved in the reconstructive surgeries by applying growth factors and tissue engineering. An extensive review of the contemporary literature was conducted according to the PRISMA guidelines by accessing the PubMed, Embase, and Scopus Elsevier databases. Authors performed the English language manuscript research published from 2003 to 2020. A total of 13 relevant studies were included in the present review. The present systematic review included only papers with significant results about correlation between scaffold, molecular features of growth factor, and reconstructive surgeries in oral maxillofacial district. The initial research with filters recorded about 1023 published papers. Beyond reading and considering of suitability, only 42 and then 36 full-text papers were recorded for the revision. All the researches recorded the possibility of using growth factors on rebuilding atrophic jaws. Different growth factors like morphogenetic factors, cytokines, and inflammatory ones and their application over different scaffold materials were recorded. Further investigations should be required in order to state scientific evidence about a clear advantage of applying tissue engineering for therapeutic purpose.

Indexed as

HumansIntercellular Signaling Peptides and ProteinsOral Surgical ProceduresPlastic Surgery ProceduresTissue EngineeringIntercellular Signaling Peptides and Proteins

Identifiers

PMID33506039
PMCPMC7808803
OpenAlexW3119298726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.