Evidence map›Paper›PMID 33506036›Full record

ArticleBioMed research international2021

Downregulation of microRNA-15b-5p Targeting the Akt3-Mediated GSK-3

Jianzhong Zhu, Xue Xu, Yingyin Liang, Ronglan Zhu

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  3. MicroRNAs and synaptic dysfunction in Parkinson's disease.Molecular therapy. Nucleic acids · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jianzhong ZhuDepartment of Neurology, Longmen County People's Hospital, Huizhou 516800, China.ORCID https://orcid.org/0000-0001-9686-218X
Xue XuDepartment of Neurology, The First Affiliated Hospital of Sun Yatsen University, Guangzhou 510080, China.
Yingyin LiangDepartment of Neurology, The First Affiliated Hospital of Sun Yatsen University, Guangzhou 510080, China.
Ronglan ZhuDepartment of Neurology, The First Affiliated Hospital of Sun Yatsen University, Guangzhou 510080, China.
Sun Yat-sen University · CNHuizhou Central People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is an incurable progressive disorder resulting from neurodegeneration, and apoptosis is considered a dominant mechanism underlying the process of neurodegeneration. MicroRNAs (miRNAs), which are small and noncoding RNAs involved in many a biological process like apoptosis and regulation of gene expressions, have been found in postmortem brain samples of patients with PD, as well as

Indexed as

AnimalsApoptosisbeta CateninCell LineCell Line, TumorCell ProliferationDisease Models, AnimalGene Expression RegulationGlycogen Synthase Kinase 3 betaHumansMaleMiceMice, Inbred C57BLMicroRNAsParkinson DiseaseProto-Oncogene Proteins c-aktAKT3 protein, humanbeta CateninCTNNB1 protein, humanGlycogen Synthase Kinase 3 betaGSK3B protein, humanMicroRNAsMIRN15 microRNA, humanProto-Oncogene Proteins c-akt

Identifiers

PMID33506036
PMCPMC7806375
OpenAlexW3118542330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.