Insulin Receptor Substrate p53 Ameliorates High-Glucose-Induced Activation of NF-

Fen Liu, Yubin Chen, Shi Zhao, Mei Li, Fanyan Luo, Can-E Tang

Open access · hybridAbstract read

In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.2field-weighted citation impact, top 56% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

Anti-inflammatory therapy of atherosclerosis: focusing on IKKβ.Journal of inflammation (London, England) · 2023
Review
Recent advances in molecular biology of metabolic syndrome pathophysiology: endothelial dysfunction as a potential therapeutic target.Journal of diabetes and metabolic disorders · 2022
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fen LiuThe Institute of Medical Science Research, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, China.

Yubin ChenDepartment of Cardiac Surgery, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, China.

Shi ZhaoThe Institute of Medical Science Research, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, China.

Mei LiThe Institute of Medical Science Research, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, China.

Fanyan LuoDepartment of Cardiac Surgery, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, China.ORCID https://orcid.org/0000-0002-1195-4585

Can-E TangThe Institute of Medical Science Research, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, China.ORCID https://orcid.org/0000-0003-2582-7613

Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes-related macrovascular and microvascular complications lead to poor prognosis. Insulin receptor substrate p53 (IRSp53) is known to act as a substrate for the insulin receptor tyrosine kinase, but its role in endothelial dysfunction remains unclear. Human umbilical vein endothelial cells (HUVECs) treated with D-glucose at different concentrations and a streptozocin-induced rat diabetes mellitus (DM) model were used to investigate the effects of hyperglycemia on the expression levels of IRSp53 and galectin-3 (gal-3) and the inflammatory state and mobility of HUVECs. Thereafter, IRSp53-overexpressing HUVECs and IRSp53-knockdown HUVECs were established using IRSp53-overexpressing lentivirus or IRSp53-siRNA to explore the role of IRSp53 in the HUVEC inflammatory state and HUVEC mobility. D-glucose at high concentration (HG) and hyperglycemia were found to induce downregulation of IRSp53 and upregulation of gal-3

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAortaBlood ProteinsCell MovementCells, CulturedDiabetes Mellitus, ExperimentalGalectinsGlucoseHumansHuman Umbilical Vein Endothelial CellsHyperglycemiaInsulinMaleNerve Tissue ProteinsNF-kappa BAdaptor Proteins, Signal TransducingBAIAP2 protein, humanBaiap2 protein, ratBlood ProteinsGalectinsGlucoseInsulinLGALS3 protein, humanNerve Tissue ProteinsNF-kappa BRNA, Small Interfering

Identifiers

PMID33506012

DOI10.1155/2021/3210586

PMCPMC7806382

OpenAlexW3119909719

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.