Evidence map›Paper›PMID 33505959›Full record

ArticleFrontiers in cell and developmental biology2020

Increased Expression of Zyxin and Its Potential Function in Androgenetic Alopecia.

Qingmei Liu, Xiangguang Shi, Yue Zhang, Yan Huang, Kai Yang, Yulong Tang, Yanyun Ma, Yuting Zhang, Ji'an Wang, Li Zhang and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Editorial: Hair Follicle Stem Cell Regeneration in Aging.Frontiers in cell and developmental biology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Qingmei LiuDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
Xiangguang ShiDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
Yue ZhangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
Yan HuangState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Kai YangDepartment of Dermatology, Jing'an District Central Hospital, Shanghai, China.
Yulong TangState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Yanyun MaState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Yuting ZhangState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Ji'an WangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
Li ZhangDepartment of Dermatology, Jing'an District Central Hospital, Shanghai, China.
Qi ZhangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
Xiao LiuDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
Jinran LinDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
Jiucun WangState Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Wenyu WuDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
Fudan University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNJingzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Androgenetic alopecia (AGA) is the most common progressive form of hair loss, occurring in more than half of men aged > 50 years. Hair follicle (HF) miniaturization is a feature of AGA, and dermal papillae (DP) play key roles in hair growth and regeneration by regulating follicular cell activity. Previous studies have revealed that adhesion signals are important factors in AGA development. Zyxin (ZYX) is an actin-interacting protein that is essential for cell adhesion and migration. The aim of this research was to investigate the expression and potential role of ZYX in AGA. Real-time polymerase chain reaction (RT-PCR) analysis revealed that ZYX expression was elevated in the affected frontal HF of individuals with AGA compared to unaffected occipital HF. Moreover, increased ZYX expression was also observed within DP using immunofluorescence staining. Our

Indexed as

androgenetic alopeciadermal papilla cellhair follicleRNA-seqZyxin

Identifiers

PMID33505959
PMCPMC7829366
OpenAlexW3119797816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.