Evidence map›Paper›PMID 33505943›Full record

ReviewCanadian journal of gastroenterology & hepatology2021

Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications.

Ana-Maria Singeap, Carol Stanciu, Laura Huiban, Cristina Maria Muzica, Tudor Cuciureanu, Irina Girleanu, Stefan Chiriac, Sebastian Zenovia, Robert Nastasa, Catalin Sfarti and 2 more

Abstract readReview
In one paragraph

Review in Canadian journal of gastroenterology & hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ana-Maria SingeapDepartment of Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID 0000-0001-5621-548X
Carol StanciuInstitute of Gastroenterology and Hepatology, "St. Spiridon" Emergency Hospital, Iasi 700111, Romania.ORCID 0000-0002-6427-4049
Laura HuibanDepartment of Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID 0000-0002-3044-0715
Cristina Maria MuzicaDepartment of Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID 0000-0003-0891-5961
Tudor CuciureanuDepartment of Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID 0000-0003-1550-8870
Irina GirleanuDepartment of Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID 0000-0001-5925-1232
Stefan ChiriacDepartment of Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID 0000-0003-2497-9236
Sebastian ZenoviaDepartment of Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID 0000-0003-0441-3980
Robert NastasaDepartment of Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID 0000-0002-8678-0663
Catalin SfartiDepartment of Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID 0000-0001-7074-5938
Camelia CojocariuDepartment of Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID 0000-0001-6395-335X
Anca TrifanDepartment of Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID 0000-0001-9144-5520

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) has a rising prevalence worldwide. Its potential for evolution towards liver cirrhosis and hepatocellular carcinoma, as well as associations with extrahepatic manifestations, represents a double burden for patients and physicians alike. Recently, there has been increasing evidence of the association between NAFLD and a number of endocrinopathies, such as hypothyroidism, polycystic ovarian syndrome (PCOS), hypopituitarism, growth hormone deficiency (GHD), hypogonadism, and hypercortisolism. Definite correlations are supported by clear evidence so far, but further studies are needed in order to completely clarify the pathogenic mechanisms and, especially, to identify therapeutic implications. In this review, we present the main relationships between NAFLD and endocrinopathies, emphasizing the reciprocal causality, evolutive interconnections, and current clinical scenarios of presentations of which the clinicians should be aware.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsNon-alcoholic Fatty Liver DiseasePolycystic Ovary SyndromeFemaleHumansLiver Cirrhosis

Identifiers

PMID33505943
PMCPMC7814954

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.