Evidence map›Paper›PMID 33505891›Full record

ArticlePediatric gastroenterology, hepatology & nutrition2021

Evidence for Differentiation of Colon Tissue Microbiota in Patients with and without Postoperative Hirschsprung's Associated Enterocolitis: A Pilot Study.

Ricardo A Arbizu, David Collins, Robert C Wilson, Alexander V Alekseyenko

Abstract read
In one paragraph

Article in Pediatric gastroenterology, hepatology & nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Observational
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ricardo A ArbizuDivision of Pediatric Gastroenterology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.ORCID https://orcid.org/0000-0003-1118-5066
David CollinsSouth Carolina Clinical and Translational Research Institute, Charleston, SC, USA.ORCID https://orcid.org/0000-0003-4691-5305
Robert C WilsonDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA.
Alexander V AlekseyenkoProgram for Human Microbiome Research, Biomedical Informatics Center, Departments of Public Health Sciences in College of Medicine; Oral Health Sciences in College of Dental Medicine; and Healthcare Leadership and Management in College of Health Professions, Medical University of South Carolina, Charleston, SC, USA.ORCID https://orcid.org/0000-0002-5748-2085

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
South Carolina Cancer Disparities Research Center (SC CaDRe)U54CA210963 · NCI · SOUTH CAROLINA STATE UNIVERSITY · PI MCCRARY-QUARLES, AUDREY · 2017 to 2023
$6.1M
Distance-based Panomic Analytics for Microbiome DataR01LM012517 · NLM · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ALEKSEYENKO, ALEXANDER V · 2018 to 2021
$1.3M
NCATS NIH HHS UL1 TR001450NCI NIH HHS U54 CA210963NLM NIH HHS R01 LM012517
6 · The paper itself

Abstract

purposeTo investigate the differences in the colon microbiota composition of Hirschsprung's disease (HSCR) patients with and without a history of postoperative Hirschsprung's associated enterocolitis (HAEC).

methodsColon tissue microbiota was characterized by bacterial deoxyribonucleic acid (DNA) extraction and 16S rDNA sequencing for taxonomic classification and comparison.

resultsThe sequence diversity richness within samples was significantly higher in samples from patients with a history of postoperative HAEC. We observed an increased relative abundance of the phyla

conclusionOur findings provide evidence that the colon tissue microbiota composition is different in HSCR patients with and without postoperative HAEC.

Indexed as

ChildrenEnterocolitisHirschsprung'sMicrobiomeMicrobiotaPediatrics

Identifiers

PMID33505891
PMCPMC7813566

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.