Evidence map›Paper›PMID 33505767›Full record

ReviewTremor and other hyperkinetic movements (New York, N.Y.)2020

Adductor Spasmodic Dysphonia Improves with Bilateral Thalamic Deep Brain Stimulation: Report of 3 Cases Done Asleep and Review of Literature.

Virgilio Gerald H Evidente, Francisco A Ponce, Maris H Evidente, Margaret Lambert, Robin Garrett, Manikandan Sugumaran, David G Lott

Open access · goldAbstract readCase ReportsReviewVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Review in Tremor and other hyperkinetic movements (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Laryngeal dystonia: a comprehensive review of aetiology, clinical presentation, diagnosis, and treatment approaches.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Review
  3. Article
  4. Review
  5. Treatment of Neurogenic Voice Disorders.World journal of otorhinolaryngology - head and neck surgery · 2025
    Review
  6. Spasmodic Dysphonia.World journal of otorhinolaryngology - head and neck surgery · 2025
    Review
  7. Article
  8. Review
  9. Significance of age and sex in botulinum neurotoxin dosing for adductor spasmodic dysphonia.World journal of otorhinolaryngology - head and neck surgery · 2023
    Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Virgilio Gerald H EvidenteMovement Disorders Center of Arizona, Scottsdale, Arizona, US.
Francisco A PonceBarrow Neurological Institute, Phoenix, Arizona, US.
Maris H EvidenteMovement Disorders Center of Arizona, Scottsdale, Arizona, US.
Margaret LambertBarrow Neurological Institute, Phoenix, Arizona, US.
Robin GarrettMovement Disorders Center of Arizona, Scottsdale, Arizona, US.
Manikandan SugumaranBanner University, Phoenix, Arizona, US.
David G LottMayo Clinic Arizona, Phoenix, Arizona, US.
Barrow Neurological Institute · USCentre for Movement Disorders · CABanner - University Medical Center Phoenix · USMayo Clinic Hospital · USSouthwest Center for Chronic Disease · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To date, there are only six published reports of adductor spasmodic dysphonia (SD) responding to awake thalamic deep brain stimulation (DBS). Methods: We retrospectively reviewed cases of Essential Tremor (ET) with SD that were seen in our center from 2012 to 2020. We further identified those that have undergone thalamic DBS, and had a blinded laryngologist rate first the audio voice recordings before and after DBS using the Unified Spasmodic Dysphonia Rating Scale (USDRS), and the video recordings last to rate the related movements and facial grimacing. Results: We identified three cases of adductor SD with ET that had undergone bilateral ventralis intermedius (VIM) DBS under general anesthesia. All patients noted improvement of their limb and voice tremor, as well as their SD post-DBS. Although improvement of tremor was observed even with initial programming in all three, improvement of SD was noted only upon reaching higher amplitudes or wider pulse widths. Blinded voice assessments showed improvement of USDRS scores post-DBS compared to pre-DBS, and with stimulator on compared to stimulator off. Discussion: We report the first three cases of SD responding favorably to bilateral VIM asleep DBS and summarize the nine cases so far of SD who have undergone thalamic DBS.

Indexed as

Ventral Thalamic NucleiAgedDeep Brain StimulationDysphoniaEssential TremorFemaleHumansMaleSpeech IntelligibilityThalamusWakefulnessDBSdeep brain stimulationEssential Tremorlaryngeal dystoniaSpasmodic dysphoniathalamic DBS

Identifiers

PMID33505767
PMCPMC7792454
OpenAlexW3117218587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.