Evidence map›Paper›PMID 33505724›Full record

ArticleBiochemistry research international2021

Diverse Effect of Vitamin C and N-Acetylcysteine on Aluminum-Induced Eryptosis.

Ali Reza Zangeneh, Mohammad Ali Takhshid, Reza Ranjbaran, Mahsa Maleknia, Mohammad Hassan Meshkibaf

Open access · goldAbstract read
In one paragraph

Article in Biochemistry research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. MnInternational journal of molecular sciences · 2025
    Article
  2. Review
  3. Article
  4. Apoptosis and eryptosis: similarities and differences.Apoptosis : an international journal on programmed cell death · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ali Reza ZangenehDepartment of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, Iran.ORCID https://orcid.org/0000-0002-5937-2314
Mohammad Ali TakhshidDiagnostic Laboratory Sciences and Technology Research Center, Faculty of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID https://orcid.org/0000-0003-0246-3765
Reza RanjbaranDiagnostic Laboratory Sciences and Technology Research Center, Faculty of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID https://orcid.org/0000-0002-8890-0999
Mahsa MalekniaDepartment of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, Iran.ORCID https://orcid.org/0000-0003-0410-132X
Mohammad Hassan MeshkibafDepartment of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, Iran.ORCID https://orcid.org/0000-0003-3583-7065
Fasa University of Medical Sciences · IRShiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe role of oxidative stress in Aluminum (Al)-induced apoptotic effects has been investigated and suicidal death of erythrocytes, eryptosis, is characterized by cell shrinkage and phosphatidylserine externalization (PSE) at the surface of the erythrocyte cell membrane. Eryptosis is stimulated by an increase in cytosolic Ca

methodsIsolated erythrocytes from the healthy volunteers were partitioned into various groups (6 replicates/group) and treated by various concentrations of Al (3-100

resultsThe results showed that a 24 hours' exposure of the erythrocytes to Al (10-100

conclusionsAl-induced eryptosis and hemolysis through triggering oxidative stress, while NAC could diverse this effect. In contrast, vit C might intensify Al-induced eryptosis at particular doses through a less known mechanism.

Identifiers

PMID33505724
PMCPMC7815388
OpenAlexW3119448260

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.