Evidence map›Paper›PMID 33505708›Full record

ArticleVirus evolution2021

Cenote-Taker 2 democratizes virus discovery and sequence annotation.

Michael J Tisza, Anna K Belford, Guillermo Domínguez-Huerta, Benjamin Bolduc, Christopher B Buck

Abstract read
In one paragraph

Article in Virus evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  19. Single cell viral tagging ofGut microbes · 2025
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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael J TiszaLab of Cellular Oncology, NCI, NIH, Bethesda, MD 20892-4263, USA.ORCID 0000-0003-1168-1617
Anna K BelfordLab of Cellular Oncology, NCI, NIH, Bethesda, MD 20892-4263, USA.
Guillermo Domínguez-HuertaDepartment of Microbiology, Ohio State University, Columbus, OH, USA.
Benjamin BolducDepartment of Microbiology, Ohio State University, Columbus, OH, USA.
Christopher B BuckLab of Cellular Oncology, NCI, NIH, Bethesda, MD 20892-4263, USA.

Funding

Molecular biology of human polyomavirusesZIABC011090 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BUCK, CHRISTOPHER · 2009 to 2025
$9.3M
6 · The paper itself

Abstract

Viruses, despite their great abundance and significance in biological systems, remain largely mysterious. Indeed, the vast majority of the perhaps hundreds of millions of viral species on the planet remain undiscovered. Additionally, many viruses deposited in central databases like GenBank and RefSeq are littered with genes annotated as 'hypothetical protein' or the equivalent. Cenote-Taker 2, a virus discovery and annotation tool available on command line and with a graphical user interface with free high-performance computation access, utilizes highly sensitive models of hallmark virus genes to discover familiar or divergent viral sequences from user-input contigs. Additionally, Cenote-Taker 2 uses a flexible set of modules to automatically annotate the sequence features of contigs, providing more gene information than comparable tools. The outputs include readable and interactive genome maps, virome summary tables, and files that can be directly submitted to GenBank. We expect Cenote-Taker 2 to facilitate virus discovery, annotation, and expansion of the known virome.

Indexed as

genome annotationprophageresearch toolviral metagenomicsvirus annotationvirus discovery

Identifiers

PMID33505708
PMCPMC7816666

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.