Evidence map›Paper›PMID 33505681›Full record

ArticleClinical & translational immunology2021

Vaccine-related major cutaneous reaction size correlates with cellular-mediated immune responses after tularaemia immunisation.

Rosangela Salerno-Gonçalves, Wilbur H Chen, Mark J Mulligan, Sharon E Frey, Jack T Stapleton, Wendy A Keitel, Jason Bailey, Eli Sendra, Heather Hill, Robert A Johnson and 1 more

Open access · goldAbstract read
In one paragraph

Article in Clinical & translational immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Emerging and Pandemic Pathogens: Lessons Learned From a Clinical Research Network.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Review
  3. Historical Advances in Clinical Trial Design and Expanding Representation as the New Frontier for Innovation.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Rosangela Salerno-GonçalvesCenter for Vaccine Development and Global Health (CVD) University of Maryland School of Medicine Baltimore MD USA.ORCID https://orcid.org/0000-0003-2999-4275
Wilbur H ChenCenter for Vaccine Development and Global Health (CVD) University of Maryland School of Medicine Baltimore MD USA.
Mark J MulliganThe Hope Clinic of the Emory Vaccine Center Department of Medicine Division of Infectious Diseases Emory University School of Medicine Decatur GA USA.
Sharon E FreyDivision of Infectious Diseases, Allergy and Immunology Saint Louis University School of Medicine St. Louis MO USA.
Jack T StapletonIowa City Veterans Administration and the University of Iowa Iowa City IA USA.
Wendy A KeitelDepartments of Molecular Virology and Microbiology, and Medicine Baylor College of Medicine Houston TX USA.
Jason BaileyEmmes Rockville MD USA.
Eli SendraEmmes Rockville MD USA.
Heather HillEmmes Rockville MD USA.
Robert A JohnsonBiomedical Advanced Research and Development Authority Department of Health and Human Services ASPR Washington DC USA.
Marcelo B SzteinCenter for Vaccine Development and Global Health (CVD) University of Maryland School of Medicine Baltimore MD USA.
Emmes (United States) · USUniversity of Maryland, Baltimore · USBaylor College of Medicine · USBiomedical Advanced Research and Development Authority · USEmory University · USSaint Louis University · USUniversity of Iowa · US

Funding

Clinical Research Career Development (RMI)K12RR023250 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2005 to 2009
$13.3M
NCRR NIH HHS K12 RR023250NIAID NIH HHS HHSN272200800001CNIAID NIH HHS HHSN272200800001GNIAID NIH HHS HHSN272200800001INIAID NIH HHS HHSN272200800001ONIAID NIH HHS HHSN272200800002CNIAID NIH HHS HHSN272200800003CNIAID NIH HHS HHSN272200800005CNIAID NIH HHS HHSN272200800008CNIAID NIH HHS HHSN272201300015CNIAID NIH HHS HHSN272201300015INIAID NIH HHS HHSN272201300018CNIAID NIH HHS HHSN272201300018INIAID NIH HHS HHSN272201300020INIAID NIH HHS HHSN272201300021CNIAID NIH HHS HHSN272201300021INIAID NIH HHS HHSN272201300022CNIAID NIH HHS HHSN272201300022INIAID NIH HHS HHSN272201500002C
6 · The paper itself

Abstract

objectives

methodsWe investigated the host T-cell-mediated immune (T-CMI) responses elicited following immunisation with LVS vaccine formulated by the DynPort Vaccine Company (DVC-LVS) or the United States Army Medical Research Institute of Infectious Diseases (USAMRIID-LVS). We compared T-CMI responses prompted by these vaccines and correlated them with take size.

resultsWe found that both LVS vaccines elicited similar T-CMI responses. Interestingly, take size associated with the T cells' ability to proliferate, secrete IFN-γ and mobilise degranulation, suggesting that these responses play an essential role in tularaemia protection.

conclusionsThese results renew the appreciation for vaccination through the scarification as a prime route of inoculation to target pathogens driving specific T-CMI responses and provide further evidence that T-CMI plays a role in protection from tularaemia.

Indexed as

humantakeT cellstularaemiavaccination

Identifiers

PMID33505681
PMCPMC7814273
OpenAlexW3123017324

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.