ArticleParkinson's disease2021
Freezing of Gait in Parkinson's Disease: Risk Factors, Their Interactions, and Associated Nonmotor Symptoms.
Article in Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Cognitive function in different motor subtypes of Parkinson's disease: A systematic review and multilevel meta-analysis.Cognitive, affective & behavioral neuroscience · 2026Pooled it
- Association Between Freezing of Gait and Sleep Quality in People with Parkinson's Disease.Brain sciences · 2026Article
- Analyzing Gait Pattern Associated With Neuropsychiatric Symptoms in Parkinson's Disease by a Comprehensive Approach.IEEE journal of translational engineering in health and medicine · 2026Article
- Identifying gait characteristics associated with freezing of gait in Parkinson's disease: An analysis of on and off medication states.Gait & posture · 2025Article
- Positive Clinical Signs in Functional Neurological Disorders: A Narrative Review and Development of a Clinical Decision Tool.Brain sciences · 2025Review
- Impacts of gait freeze on quality of life in Parkinson's disease, from the perspectives of patients and their carers.Irish journal of medical science · 2024Article
- Unveiling the Unpredictable in Parkinson's Disease: Sensor-Based Monitoring of Dyskinesias and Freezing of Gait in Daily Life.Bioengineering (Basel, Switzerland) · 2024Article
- Investigating spatiotemporal and kinematic gait parameters in individuals with Parkinson's disease with a history of freezing of gait and exploring the effects of dopaminergic therapy on freezing of gait subtypes.Frontiers in neuroscience · 2024Article
- Association of Depression With Early Occurrence of Postural Instability in Parkinson's Disease.Journal of movement disorders · 2023Article
- Baseline cerebral structural morphology predict freezing of gait in early drug-naïve Parkinson's disease.NPJ Parkinson's disease · 2022Article
- The Ziegler Test Is Reliable and Valid for Measuring Freezing of Gait in People With Parkinson Disease.Physical therapy · 2022Article
- Classification of Parkinson's disease motor phenotype: a machine learning approach.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- MRI biomarkers of freezing of gait development in Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Freezing of Gait in Multiple System Atrophy.Frontiers in aging neuroscience · 2022Article
- A Video Self-Modeling Intervention Using Virtual Reality Plus Physical Practice for Freezing of Gait in Parkinson Disease: Feasibility and Acceptability Study.JMIR formative research · 2021Article
- Assessment of Risk Factors for Falls among Patients with Parkinson's Disease.BioMed research international · 2021Article
- Future Therapeutic Strategies for Freezing of Gait in Parkinson's Disease.Frontiers in human neuroscience · 2021Review
- Comparing the Clinical and Neuropsychological Characteristics of Parkinson's Disease With and Without Freezing of Gait.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFreezing of gait (FOG) is a debilitating and incompletely understood symptom in Parkinson's disease (PD).
objectiveTo determine the principal clinical factors predisposing to FOG in PD, their interactions, and associated nonmotor symptoms.
methods164 PD subjects were assessed in a cross-sectional retrospective study, using the MDS-UPDRS scale, MMSE, and Clinical Dementia Rating Scale. Clinical factors associated with FOG were determined using univariate analysis and nominal logistic regression. Receiver operating characteristic curves were computed, to obtain measures of sensitivity and specificity of predictors of FOG. Subgroups of patients with FOG were compared with those without FOG, based on defining aspects of their clinical phenotype.
resultsRelative to non-FOG patients, those with FOG had a longer disease duration, higher PIGD and balance-gait score, higher LED, and more motor complications (
conclusionsBoth disease and treatment-related factors, notably LED, influence the risk of FOG in PD, with a selective influence of cognitive dysfunction in patients with balance-gait disorder but not in those with motor fluctuations. These findings may help to inform clinical management and highlight distinct subgroups of patients with PD-FOG, which are likely to differ in their network pathophysiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.