Evidence map›Paper›PMID 33505402›Full record

ArticleFrontiers in immunology2020

FcγRIIb Expression Is Decreased on Naive and Marginal Zone-Like B Cells From Females With Multiple Sclerosis.

Stephanie Trend, Jonatan Leffler, Ingrid Teige, Björn Frendéus, Allan G Kermode, Martyn A French, Prue H Hart

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Stephanie TrendInflammation Laboratory, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.
Jonatan LefflerInflammation Laboratory, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.
Ingrid TeigeDemyelinating Diseases Research Group, BioInvent International AB, Lund, Sweden.
Björn FrendéusDemyelinating Diseases Research Group, BioInvent International AB, Lund, Sweden.
Allan G KermodePerron Institute for Neurological and Translational Science, University of Western Australia, Perth, WA, Australia.
Martyn A FrenchMedical School and School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.
Prue H HartInflammation Laboratory, Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.
University of Western Australia · AUBioInvent (Sweden) · SEPerron Institute for Neurological and Translational Science · AUThe Kids Research Institute Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B cells are critical to the development of multiple sclerosis (MS), but the mechanisms by which they contribute to the disease are poorly defined. We hypothesised that the expression of CD32b (FcγRIIb), a receptor for the Fc region of IgG with inhibitory activities in B cells, is lower on B cell subsets from people with clinically isolated syndrome (CIS) or MS. CD32b expression was highest on post-naive IgM

Indexed as

AdultAntibodies, ViralB-Cell Activating FactorB-LymphocytesB-Lymphocyte SubsetsCytokinesFemaleHerpesvirus 4, HumanHumansImmunoglobulin GImmunoglobulin MInterleukin-10Middle AgedMultiple SclerosisReceptors, IgGToll-Like Receptor 7Antibodies, ViralB-Cell Activating FactorCytokinesFc gamma receptor IIBIL10 protein, humanImmunoglobulin GImmunoglobulin MInterleukin-10Receptors, IgGTLR7 protein, humanTNFSF13B protein, humanToll-Like Receptor 7Tumor Necrosis Factor-alphaB cellsEpstein-Barr virusFcγRIIbfemalesimmune regulationmultiple sclerosis

Identifiers

PMID33505402
PMCPMC7832177
OpenAlexW3119524177

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.