ArticleFrontiers in systems neuroscience2020
Perceptual Behavior Depends Differently on Pupil-Linked Arousal and Heartbeat Dynamics-Linked Arousal in Rats Performing Tactile Discrimination Tasks.
Article in Frontiers in systems neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Transcutaneous cervical vagus nerve stimulation improves sensory performance in humans: a randomized controlled crossover pilot study.Scientific reports · 2024Trial
- Article
- Linking reaction time variability to physiological markers of arousal across timescales.bioRxiv : the preprint server for biology · 2026Article
- The Contribution of the Locus Ceruleus-Norepinephrine System to the Coupling between Pupil-Linked Arousal and Cortical State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Behavioral state-dependent norepinephrine dynamics in the primary somatosensory and prefrontal cortices during tactile detection tasks.bioRxiv : the preprint server for biology · 2026Article
- When your heart isn't in it anymore: cardiac correlates of task disengagement.Communications biology · 2025Article
- Bidirectional modulation of somatostatin-expressing interneurons in the basolateral amygdala reduces neuropathic pain perception in mice.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Optimization of Temporal Coding of Tactile Information in Rat Thalamus by Locus Coeruleus Activation.Biology · 2024Article
- Adaptive decision-making depends on pupil-linked arousal in rats performing tactile discrimination tasks.Journal of neurophysiology · 2023Article
- Review
- Classification of Contrasting Discrete Emotional States Indicated by EEG Based Graph Theoretical Network Measures.Neuroinformatics · 2022Article
- The Neuromodulatory Role of the Noradrenergic and Cholinergic Systems and Their Interplay in Cognitive Functions: A Focused Review.Brain sciences · 2022Review
- Rapid Effects of Vagus Nerve Stimulation on Sensory Processing Through Activation of Neuromodulatory Systems.Frontiers in neuroscience · 2022Review
Corrections and comments
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Authors and funding
4 authors.
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Abstract
Several physiology signals, including heart rate and pupil size, have been widely used as peripheral indices of arousal to evaluate the effects of arousal on brain functions. However, whether behavior depends differently on arousal indexed by these physiological signals remains unclear. We simultaneously recorded electrocardiogram (ECG) and pupil size in head-fixed rats performing tactile discrimination tasks. We found both heartbeat dynamics and pupil size co-varied with behavioral outcomes, indicating behavior was dependent upon arousal indexed by the two physiological signals. To estimate the potential difference between the effects of pupil-linked arousal and heart rate-linked arousal on behavior, we constructed a Bayesian decoder to predict animals' behavior from pupil size and heart rate prior to stimulus presentation. The performance of the decoder was significantly better when using both heart rate and pupil size as inputs than when using either of them alone, suggesting the effects of the two arousal systems on behavior are not completely redundant. Supporting this notion, we found that, on a substantial portion of trials correctly predicted by the heart rate-based decoder, the pupil size-based decoder failed to correctly predict animals' behavior. Taken together, these results suggest that pupil-linked and heart rate-linked arousal systems exert different influences on animals' behavior.
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