ArticleFrontiers in neuroscience2020
Less Is Better: Single-Digit Brain Functional Connections Predict T2DM and T2DM-Induced Cognitive Impairment.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Structural and functional brain abnormal alteration in patients with type 2 diabetes mellitus: A coordinate-based meta-analysis.Translational psychiatry · 2025Pooled it
- Changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods: A new coordinate-based meta-analysis of neuroimaging.Frontiers in neurology · 2022Pooled it
- Spontaneous brain activity in patients with type 2 diabetes: linking serum neuroproteins to cognitive ability.Diabetology & metabolic syndrome · 2025Article
- Functional connectivity density aberrance in type 2 diabetes mellitus with and without mild cognitive impairment.Frontiers in neurology · 2024Article
- Cortical gray matter microstructural alterations in patients with type 2 diabetes mellitus.Brain and behavior · 2022Article
- Machine Learning for Detecting Parkinson's Disease by Resting-State Functional Magnetic Resonance Imaging: A Multicenter Radiomics Analysis.Frontiers in aging neuroscience · 2022Article
- Functional Brain Connections Identify Sensorineural Hearing Loss and Predict the Outcome of Cochlear Implantation.Frontiers in computational neuroscience · 2022Article
- Altered functional hubs and connectivity in type 2 diabetes mellitus with and without mild cognitive impairment.Frontiers in neurology · 2022Article
- Integrating Structural and Functional Interhemispheric Brain Connectivity of Gait Freezing in Parkinson's Disease.Frontiers in neurology · 2021Article
- Altered Degree Centrality of Brain Networks in Parkinson's Disease With Freezing of Gait: A Resting-State Functional MRI Study.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes mellitus (T2DM) leads to a higher risk of brain damage and adversely affects cognition. The underlying neural mechanism of T2DM-induced cognitive impairment (T2DM-CI) remains unclear. This study proposes to identify a small number of dysfunctional brain connections as imaging biomarkers, distinguishing between T2DM-CI, T2DM with normal cognition (T2DM-NC), and healthy controls (HC). We have recruited 22 T2DM-CI patients, 31 T2DM-NC patients, and 39 HCs. The structural Magnetic Resonance Imaging (MRI) and resting state fMRI images are acquired, and neuropsychological tests are carried out. Amplitude of low frequency fluctuations (ALFF) is analyzed to identify impaired brain regions implicated with T2DM and T2DM-CI. The functional network is built and all connections connected to impaired brain regions are selected. Subsequently, L
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