Evidence map›Paper›PMID 33505219›Full record

ArticleMediators of inflammation2021

Changes in Sepsis Biomarkers after Immunosuppressant Administration in Transplant Patients.

Janka Franeková, Marek Protuš, Eva Kieslichová, Aleš Březina, Jitka Komrsková, Jiří Vymětalík, Antonín Jabor

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Janka FranekováDepartment of Laboratory Methods, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic.ORCID https://orcid.org/0000-0002-5094-7724
Marek ProtušDepartment of Anesthesiology, Resuscitation, and Intensive Care, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic.ORCID https://orcid.org/0000-0002-6595-6877
Eva KieslichováDepartment of Anesthesiology, Resuscitation, and Intensive Care, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic.ORCID https://orcid.org/0000-0002-3930-623X
Aleš BřezinaDepartment of Anesthesiology and Resuscitation, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic.ORCID https://orcid.org/0000-0002-5969-7602
Jitka KomrskováDepartment of Laboratory Methods, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic.ORCID https://orcid.org/0000-0003-2499-7194
Jiří VymětalíkDepartment of Laboratory Methods, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic.ORCID https://orcid.org/0000-0002-8453-969X
Antonín JaborDepartment of Laboratory Methods, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21 Prague 4, Czech Republic.ORCID https://orcid.org/0000-0002-4144-3129
Charles University · CZInstitute of Clinical and Experimental Medicine · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis biomarkers change continuously during the postoperative period. We aimed to demonstrate the influence of immunosuppressants after transplantation (Tx) on presepsin, procalcitonin, CRP, white blood cells, and IL-6. A group of 140 patients after major surgery (86 non-Tx, 54 Tx) without any signs of sepsis or infectious complications was followed for 7 days. The changes in biomarkers were analyzed with respect to the type of surgery, organ, and induction immunosuppressant used (antithymocyte globulin, corticosteroids, or basiliximab/rituximab). Concentrations (95th percentiles) of presepsin and procalcitonin were higher in the Tx group (presepsin: Tx < 2380 vs. non-Tx < 1368 ng/L,

Indexed as

AgedBiomarkersC-Reactive ProteinFemaleHumansImmunosuppressive AgentsInterleukin-6MaleMiddle AgedSepsisBiomarkersC-Reactive ProteinImmunosuppressive AgentsInterleukin-6

Identifiers

PMID33505219
PMCPMC7811562
OpenAlexW3118461588

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.