ArticleNature2021
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition.
Open access · bronzeAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers.
0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed
24.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
189 citing papers in PubMed, 283 citations in OpenAlex.
- KIF18A inhibitor prevents chromosomally unstable osteosarcoma growth by activating spindle assembly checkpoint.Cancer biology & therapy · 2026Article
- Power-law scaling of mitotic spindles with genome sizes across eukaryotes is driven by chromosome crowding.Nature cell biology · 2026Article
- Chromosomal instability in cancer: sources, consequences and new therapeutic opportunities.Signal transduction and targeted therapy · 2026Review
- Infection and α-ketoglutarate/oxygen inhibition converge to CDC20 to promote cancer cell aneuploidy.Signal transduction and targeted therapy · 2026Article
- Deficiency in POLE Exonuclease Causes Synthetic Lethality in Highly Aneuploid Cancer Cells.Cancer research · 2026Article
- Article
- Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer.Cancer research communications · 2026Article
- Paediatric therapeutic development workshop on osteosarcoma.British journal of cancer · 2026Review
- Tetraploids or polyploid giants: who is truly dangerous?Trends in cell biology · 2026Review
- BAP1 deficiency-induced SKA3 promotes clear cell renal cell carcinoma malignant progression by regulating chromosomal instability.Cell death & disease · 2026Article
- Context-dependent synthetic lethality - an emerging precision therapeutic approach.Nature reviews. Cancer · 2026Review
- Article
- Genomic Catastrophe Defines the Evolutionary Trajectory of Adrenocortical Carcinoma.Endocrine pathology · 2026Article
- Molecular and Cell Biological Characterization of Patient-Derived Head and Neck Squamous Carcinoma Cell Lines.Cancer science · 2026Article
- Aneuploidy sensitizes cells to SREBP-pathway inhibition in squamous cell carcinoma.bioRxiv : the preprint server for biology · 2026Article
- Cell and Nuclear Size Is Associated with Chromosomal Instability and Tumorigenicity in Cancer Cells That Undergo Whole Genome Doubling.Cancer research · 2026Article
- Loss of JAK1 Function Causes G2-M Cell-Cycle Defects Vulnerable to KIF18A Inhibition.Cancer research · 2026Article
- Combinatorial effects of multiple genes contribute to beneficial aneuploidy phenotypes.EMBO reports · 2026Article
- Paired CRISPR screens identify mitochondrial metabolism and UBE2H as aneuploid-specific dependencies in human cancer cell lines.bioRxiv : the preprint server for biology · 2026Article
- KIF18A Maintains Kinetochore-Microtubule Attachments in CIN Cells by Limiting Microtubule Polymerization.bioRxiv : the preprint server for biology · 2026Article
129 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 7 institutions in 5 countries.
Yael Cohen-SharirDepartment of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
James M McFarlandCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9978-480X
Mai AbdusamadCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Carolyn MarquisDepartment of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT, USA.
Sara V BernhardDepartment of Molecular Genetics, TU Kaiserlautern, Kaiserlautern, Germany.
Mariya KazachkovaCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Helen TangCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Marica R IppolitoDepartment of Experimental Oncology at IEO, European Institute of Oncology IRCCS, Milan, Italy.
Kathrin LaueDepartment of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Johanna ZerbibDepartment of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Heidi L H MalabyDepartment of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT, USA.
Andrew JonesCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Lisa-Marie StautmeisterDepartment of Molecular Genetics, TU Kaiserlautern, Kaiserlautern, Germany.
Irena BockajEuropean Research Institute for the Biology of Aging (ERIBA), University of Groningen, Groningen, The Netherlands.
René WardenaarEuropean Research Institute for the Biology of Aging (ERIBA), University of Groningen, Groningen, The Netherlands.
Nicholas LyonsCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ankur NagarajaCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8586-3117
Adam J BassCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8193-4758
Diana C J SpieringsEuropean Research Institute for the Biology of Aging (ERIBA), University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-8403-474X
Floris FoijerEuropean Research Institute for the Biology of Aging (ERIBA), University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-0989-3127
Rameen BeroukhimCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6303-3609
Stefano SantaguidaDepartment of Experimental Oncology at IEO, European Institute of Oncology IRCCS, Milan, Italy.ORCID http://orcid.org/0000-0002-1501-6190
Todd R GolubCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-0113-2403
Jason StumpffDepartment of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT, USA.
Zuzana StorchováDepartment of Molecular Genetics, TU Kaiserlautern, Kaiserlautern, Germany.ORCID http://orcid.org/0000-0003-2376-7047
Uri Ben-DavidDepartment of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. ubendavid@tauex.tau.ac.il.ORCID http://orcid.org/0000-0001-7098-2378
Broad Institute · USTel Aviv University · ILUniversity of Groningen · NLUniversity of Kaiserslautern · DEUniversity of Vermont · USEuropean Institute of Oncology · ITUniversity of Milan · IT
Funding
Tuning Mitotic Kinesins Through Motor Domain Post Translational ModificationsR01GM130556 · NIGMS · MAYO CLINIC JACKSONVILLE · PI GROSS, STEVEN P, MURETTA, JOSEPH M. · 2019 to 2022
$2.4MSpatial and temporal control of mitotic chromosome movements.R01GM121491 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI STUMPFF, JASON K · 2017 to 2021
$1.8MNIGMS NIH HHS R01 GM121491NIGMS NIH HHS R01 GM130556
Abstract
Selective targeting of aneuploid cells is an attractive strategy for cancer treatment
Indexed as
AneuploidyAbnormal KaryotypeCell Line, TumorCell ProliferationChromosome SegregationDiploidyGenes, LethalHumansKinesinsM Phase Cell Cycle CheckpointsNeoplasmsSpindle ApparatusSynthetic Lethal MutationsTime FactorsKIF18A protein, humanKinesins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.