ArticleNature2021
Whole-genome doubling confers unique genetic vulnerabilities on tumour cells.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 180 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed, 2 pooled it
21.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
180 citing papers in PubMed, 2 syntheses or guidelines pooled it, 261 citations in OpenAlex.
- Inflamed Yet Immune-Evasive? A Transcriptomic Meta-Analysis Identifies Conserved Inflammatory, Developmental, and Neuronal Signatures Associated with Polyploid Giant Cancer Cells.International journal of molecular sciences · 2026Pooled it
- Systemic Alterations of Cancer Cells and Their Boost by Polyploidization: Unicellular Attractor (UCA) Model.International journal of molecular sciences · 2023Pooled it
- Trial
- KIF18A inhibitor prevents chromosomally unstable osteosarcoma growth by activating spindle assembly checkpoint.Cancer biology & therapy · 2026Article
- Heterogeneity in cancer: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Chromosomal instability in cancer: sources, consequences and new therapeutic opportunities.Signal transduction and targeted therapy · 2026Review
- Ensemble learning of pathology foundation models for precision oncology.Cancer cell · 2026Article
- Ploidy-Dependent Response to Anticancer Drugs of Human Embryonic Stem Cells.Cell proliferation · 2026Article
- Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer.Cancer research communications · 2026Article
- Paediatric therapeutic development workshop on osteosarcoma.British journal of cancer · 2026Review
- Tetraploids or polyploid giants: who is truly dangerous?Trends in cell biology · 2026Review
- Charting intratumor heterogeneity from bench to bedside.Nature cancer · 2026Review
- BAP1 deficiency-induced SKA3 promotes clear cell renal cell carcinoma malignant progression by regulating chromosomal instability.Cell death & disease · 2026Article
- Article
- A tumor profiling resource for ovarian cancer: insights into chemotherapy-driven heterogeneity and personalized treatment strategy.Nature communications · 2026Article
- Ploidy shapes gemcitabine response through altered potency and delayed cell death.bioRxiv : the preprint server for biology · 2026Article
- Growth under pressure: The pros and cons of polyploidy induced by stress.Proceedings of the National Academy of Sciences of the United States of America · 2026Review
- Oxidative stress and serum deprivation influence the evolution of newly formed tetraploid cells during tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Rethinking ovarian cancer III: the past decade and future directions.Nature reviews. Cancer · 2026Review
- Pervasive chromosomal instability drives the karyotypic evolution of hypodiploid tumours.Genome medicine · 2026Article
120 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 4 institutions in 2 countries.
Ryan J QuintonDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Amanda DiDomizioDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Marc A VittoriaDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Kristýna KotýnkováDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Carlos J TicasDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Sheena PatelDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Yusuke KogaDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
Jasmine VakhshoorzadehDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Nicole HermanceDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, USA.
Taruho S KurodaDepartment of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Mie, Japan.
Neha ParulekarDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
Alison M TaylorDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Amity L ManningDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, USA.
Joshua D CampbellDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0780-8662
Neil J GanemDepartment of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA. nganem@bu.edu.ORCID http://orcid.org/0000-0003-0269-6585
Boston University · USBroad Institute · USWorcester Polytechnic Institute · USMie University · JP
Funding
Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3MRegulation of cell growth and proliferation by the Hippo pathwayR01GM117150 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NEIL J. GANEM · 2016 to 2026
$2.4MDefining novel pathways that arrest genetically unstable tetraploid cellsR00CA154531 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GANEM, NEIL J. · 2013 to 2015
$723kDefining novel pathways that arrest genetically unstable tetraploid cellsK99CA154531 · NCI · DANA-FARBER CANCER INST · PI GANEM, NEIL J. · 2011 to 2012
$300kDefining Novel Mechanisms of Genome Instability in BRAF-mutant MelanomaF30CA228388 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI VITTORIA, MARC ANTHONY · 2018 to 2022
$253kNCATS NIH HHS UL1 TR001430NCI NIH HHS F30 CA228388NCI NIH HHS K99 CA154531NCI NIH HHS R00 CA154531NIGMS NIH HHS R01 GM117150NIH HHS 1UL1TR001430
Abstract
Whole-genome doubling (WGD) is common in human cancers, occurring early in tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour development
Indexed as
TetraploidyAbnormal KaryotypeCell Line, TumorFemaleGenes, LethalGenome, HumanHumansKinesinsMaleMitosisM Phase Cell Cycle CheckpointsNeoplasmsProteasome Endopeptidase ComplexReproducibility of ResultsSpindle ApparatusKIF18A protein, humanKinesinsProteasome Endopeptidase Complex
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.