ArticleNature2021
A growth-factor-activated lysosomal K
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 72 papers.
0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
72 citing papers in PubMed, 113 citations in OpenAlex.
- Lysosomal dysfunction in neurodegenerative disease.Nature reviews. Neurology · 2026Review
- A nonhydrolyzable candesartan cilexetil analog reveals synergistic activation as a tractable mechanism for TMEM175 modulation.American journal of physiology. Cell physiology · 2026Article
- Bidirectional communication between the gut microbiota and the central nervous system.Neural regeneration research · 2026Article
- TMEM175 rescues post-infarct cardiac dysfunction via mTORC1-lysosomal axis modulation.Acta pharmacologica Sinica · 2026Article
- Enterococcus hirae QT4713-derived dopamine ameliorates intestinal inflammation and MPTP-induced Parkinson's disease in mice.NPJ Parkinson's disease · 2026Article
- The SHIP1-inflammatory-lipid axis in Alzheimer's disease: from genetic risk to spatiotemporal mechanistic insights.Journal of neuroinflammation · 2026Review
- Deficiency of lysosomal TMEM175 in myeloid macrophages exerts anti-tumor immunity via inflammasome and cross-presentation pathway.Nature communications · 2026Article
- TMEM175 does not function as a proton-selective ion channel to prevent lysosomal over-acidification.The Journal of cell biology · 2026Article
- Targeting TMEM175 in Lysosomal Physiology and Human Diseases.Current stem cell research & therapy · 2026Review
- Autophagy-lysosomal pathway in neurodegeneration.Molecular neurodegeneration advances · 2026Review
- A guide to selecting high-performing antibodies for TMEM175 (UniProt ID: Q9BSA9) for use in western blot, immunoprecipitation, and immunofluorescence.F1000Research · 2026Article
- INPP5D/SHIP1 is a dual regulator of endo-lysosome function and selective phagocytosis in human microglia.bioRxiv : the preprint server for biology · 2025Article
- Tackling a disease on a global scale, the Global Parkinson's Genetics Program, GP2: A new generation of opportunities.American journal of human genetics · 2025Review
- Identification of a large anion channel required for digestive vacuole acidification and amino acid export in Plasmodium falciparum.PLoS biology · 2025Article
- Lysosomes as Dynamic Regulators of Metabolic Signaling and Organ Physiology in Aging: From Mechanism to Therapy.Aging and disease · 2025Review
- Identification of Common Brain Protein and Genetic Loci Between Parkinson's Disease and Lewy Body Dementia.CNS neuroscience & therapeutics · 2025Article
- CYP51A1 drives resistance to pH-dependent cell death in pancreatic cancer.Nature communications · 2025Article
- Lysosomal Ion Channels and Transporters: Recent Findings, Therapeutic Potential, and Technical Approaches.Bioelectricity · 2025Review
- Deep Learning-Based Ion Channel Kinetics Analysis for Automated Patch Clamp Recording.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Energy metabolism in health and diseases.Signal transduction and targeted therapy · 2025Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
15 authors at 3 institutions in 2 countries.
Jinhong WieDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1095-8867
Zhenjiang LiuDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Haikun SongState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, School of Life Sciences, Fudan University, Shanghai, China.
Thomas F TropeaDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lu YangSchool of Life Sciences, IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
Huanhuan WangSchool of Life Sciences, IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
Yuling LiangCenter for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Chunlei CangDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3302-0927
Kimberly ArandaDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Joey LohmannDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Jing YangSchool of Life Sciences, IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-2048-735X
Boxun LuState Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, School of Life Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-1675-9340
Alice S Chen-PlotkinDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. chenplot@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-3387-2038
Kelvin C LukCenter for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. kelvincl@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-6591-6269
Dejian RenDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA. dren@sas.upenn.edu.ORCID http://orcid.org/0000-0002-6592-9457
University of Pennsylvania · USPeking University · CNFudan University · CN
Funding
UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3MVIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Patrick Seale · 1986 to 2026
$48.3MTRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI REBECCA G WELLS · 1997 to 2026
$32.5MProject IV: "Alpha-Synuclein Strains & Diverse Synucleinopathies"P50NS053488 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2007 to 2017
$20.9MProject IV "Tackling Heterogeneity of Cognitive Trajectory in LBD"U19AG062418 · NIA · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2019 to 2023
$18.1MPropagation of Lewy pathology in Parkinsons diseaseR01NS088322 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LUK, KELVIN C · 2015 to 2025
$4.0MBiomarkers of cognitive decline in Parkinson's DiseaseR01NS115139 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI CHEN-PLOTKIN, ALICE S · 2019 to 2023
$3.6MRegulation of lysosomal potassium channelsR01GM133172 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Dejian Ren · 2019 to 2026
$2.0MVoltage-gated sodium channels in lysosomal physiologyR01HL147379 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI REN, DEJIAN · 2019 to 2022
$2.0MThe Role of Alzheimer's Disease Genetic Risk in Predicting Parkinson's Disease DementiaK23NS114167 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TROPEA, THOMAS FRANCIS · 2020 to 2024
$985kNCI NIH HHS P30 CA016520NHLBI NIH HHS R01 HL147379NIA NIH HHS U19 AG062418NIDDK NIH HHS P30 DK019525NIDDK NIH HHS P30 DK050306NIGMS NIH HHS R01 GM133172NINDS NIH HHS K23 NS114167NINDS NIH HHS P50 NS053488NINDS NIH HHS R01 NS088322NINDS NIH HHS R01 NS115139
Abstract
Lysosomes have fundamental physiological roles and have previously been implicated in Parkinson's disease
Indexed as
alpha-SynucleinAnimalsBiocatalysisDopaminergic NeuronsFemaleGain of Function MutationHEK293 CellsHumansIntercellular Signaling Peptides and ProteinsLoss of Function MutationLysosomesMaleMiceMice, KnockoutMotor SkillsMultiprotein Complexesalpha-SynucleinIntercellular Signaling Peptides and ProteinsMultiprotein ComplexesPotassiumPotassium ChannelsProto-Oncogene Proteins c-aktTMEM175 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.