ArticleNature2021
Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury.
4 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 99 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 2 pooled it
18.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury
Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury
Study on Preliminary Safety and Efficacy of Epidural Electrical Stimulation to Manage Lower Urinary Tract Dysfunction After Spinal Cord Injury
Who cites it
99 citing papers in PubMed, 2 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- Spinal cord stimulation to manage autonomic dysfunction after spinal cord injury: a systematic review.Frontiers in human neuroscience · 2026Pooled it
- Strategies to Augment the Cardiovascular System and Acutely Enhance Exercise Performance in Individuals with Spinal Cord Injury: A Systematic Scoping Review.Sports medicine - open · 2025Pooled it
- Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial.Nature medicine · 2024Trial
- Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis.Nature medicine · 2022Trial
- Exercise and Autonomic Cardiovascular Function-Insights From Spinal Cord-Injured Humans: A Narrative Review.Acta physiologica (Oxford, England) · 2026Review
- In conversation with Grégoire Courtine.Nature neuroscience · 2026Article
- Association between blood pressure instability and health-related quality of life in people with spinal cord injury.Spinal cord · 2026Article
- A biodegradable piezoelectric vertebral implant for programmable electro-neuromodulation in spinal cord injury.Science advances · 2026Article
- Surface circumferential spinal cord recording in freely moving rodents.Nature communications · 2026Article
- Spinal cord neuromodulation for autonomic recovery following spinal cord injury: a scoping review.Journal of neuroengineering and rehabilitation · 2026Article
- Validating the ADFSCI hypotension symptom domain as a scalable patient reported outcome measure in spinal cord injury.NPJ digital medicine · 2026Article
- Multimodal, device-based therapeutic targeting of the cardiovascular autonomic nervous system.Nature reviews. Cardiology · 2026Review
- Perilesional neuromodulation replaces lost sensorimotor function in persons with spinal cord injury.Nature biomedical engineering · 2026Article
- Magnetically Responsive Piezoelectric Nanocapacitors Enhance Neural Recovery Following Spinal Cord Injury via Targeted Spinal Magnetic Stimulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Effective management of orthostatic hypotension in a patient with complete spinal cord injury using a portable transcutaneous spinal cord stimulation device: A case report.The journal of spinal cord medicine · 2026Article
- Electroceuticals for Paralympic Athletes: A Fair Play and Classification Concern?Sports medicine (Auckland, N.Z.) · 2026Review
- Article
- Advances in Bionic Therapies for Targeting Neural Circuit Reconstruction and Integration for Spinal Cord Injury.Cellular and molecular neurobiology · 2025Review
- Article
- Neuroprosthetic closed-loop strategy for sustained blood pressure reduction via simultaneous stimulation and recording from the spinal cord.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
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Authors and funding
47 authors at 12 institutions in 5 countries.
Jordan W SquairCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-0551-859X
Matthieu Gautier *Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-4910-8576
Lois Mahe *Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Jan Elaine Soriano *Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Andreas Rowald *Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Arnaud BichatCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Newton ChoCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Mark A AndersonCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Nicholas D JamesCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Jerome GandarCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Anthony V IncognitoRestoreNetwork, Hotchkiss Brain Institute, Libin Cardiovascular Institute, McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Giuseppe SchiavoneCentre for Neuroprosthetics, Institute of Microengineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-7121-9825
Zoe K SarafisCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-4149-1099
Achilleas LaskaratosCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-2456-5781
Kay BartholdiCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Robin DemesmaekerCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-0856-0929
Salif KomiCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Charlotte MoermanDepartment of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Bita VaseghiDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Berkeley ScottDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Ryan RosentreterDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Claudia KatheCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-6441-1755
Jimmy RavierCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Laura McCrackenCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Xiaoyang KangCentre for Neuroprosthetics, Institute of Microengineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Nicolas VachicourasCentre for Neuroprosthetics, Institute of Microengineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-5073-2312
Florian FalleggerCentre for Neuroprosthetics, Institute of Microengineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Ileana JelescuCenter for Biomedical Imaging, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-3664-0195
YunLong ChengMotac Neuroscience Ltd, Manchester, UK.
Qin LiMotac Neuroscience Ltd, Manchester, UK.
Rik BuschmanMedtronic, Minneapolis, MN, USA.
Nicolas BuseMedtronic, Minneapolis, MN, USA.
Tim DenisonDepartment of Engineering Science and Clinical Neurosciences, University of Oxford, Oxford, UK.
Sean DukelowDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Rebecca CharbonneauDepartment of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Ian RigbyDepartment of Emergency Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Steven K BoydDepartment of Radiology, McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Alberta, Canada.
Philip J MillarDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.ORCID http://orcid.org/0000-0002-2177-1061
Eduardo Martin MoraudDepartment of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Marco CapogrossoFaculty of Biology, University of Fribourg, Fribourg, Switzerland.
Fabien B WagnerCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-9582-6109
Quentin BarraudCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Erwan BezardMotac Neuroscience Ltd, Manchester, UK.ORCID http://orcid.org/0000-0002-0410-4638
Stéphanie P LacourCentre for Neuroprosthetics, Institute of Microengineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-9075-4022
Jocelyne BlochCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Grégoire CourtineCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland. gregoire.courtine@epfl.ch.ORCID http://orcid.org/0000-0002-5744-4142
Aaron A PhillipsDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. aaron.phillips@ucalgary.ca.ORCID http://orcid.org/0000-0002-7845-1464
École Polytechnique Fédérale de Lausanne · CHUniversity of Calgary · CAMedtronic (United States) · USMotac Neuroscience (United Kingdom) · GBCentre National de la Recherche Scientifique · FRUniversité de Bordeaux · FRUniversity Hospital of Lausanne · CHUniversity of British Columbia · CAUniversity of Fribourg · CHUniversity of Guelph · CAUniversity of Oxford · GBUniversity of Toronto · CA
Funding
European Research Council
Abstract
Spinal cord injury (SCI) induces haemodynamic instability that threatens survival
Indexed as
BaroreflexBiomimeticsHemodynamicsProstheses and ImplantsAnimalsDisease Models, AnimalFemaleHumansMaleNeural PathwaysPrimatesRatsRats, Inbred LewSpinal Cord InjuriesSympathetic Nervous System
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT04994886ClinicalTrials.gov
NCT05044923ClinicalTrials.gov
NCT05111093ClinicalTrials.gov
NCT06845904ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.