ArticleNature2021
Inceptor counteracts insulin signalling in β-cells to control glycaemia.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
13.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- GLP-1 receptor agonists and pancreatic beta cell apoptosis in diabetes mellitus: a systematic review and meta-analysis of preclinical studies.Frontiers in clinical diabetes and healthcare · 2025Pooled it
- Transcriptional targets of amyotrophic lateral sclerosis/frontotemporal dementia protein TDP-43 - meta-analysis and interactive graphical database.Disease models & mechanisms · 2022Pooled it
- Insulin mimetics and non-canonical insulin receptor signaling: mechanisms and disease relevance.Experimental & molecular medicine · 2026Review
- Proteomic analysis of pancreatic endocrine cells by mechanistic single-cell isolation identifies membrane pathways.Experimental & molecular medicine · 2026Article
- Insulin receptor trafficking and interactions in muscle cells.Journal of the Endocrine Society · 2026Article
- ELAPOR1 mediated vesicle traffic is required for acrosome biogenesis and male fertility in mice.Cellular and molecular life sciences : CMLS · 2026Article
- Peptide hormone spexin restores beta cell function and improves glycaemic control in mice via regulation of the sodium-potassium pump.Diabetologia · 2026Article
- Genetic recording of pancreatic beta cell proliferation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Lost in translation: absence of KIAA1324/ELAPOR1 protein in pathological TDP-43-affected neurons in ALS/FTD.Acta neuropathologica communications · 2026Article
- ELAPOR1 regulates VPS54-mediated GARP complex formation and proacrosomal vesicle fusion during spermatogenesis.Theranostics · 2026Article
- The Central Role of Lipid Metabolism Disorders in Diabetes Mellitus: Mechanisms, Clinical Manifestations, and Emerging Therapeutic Strategies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Single-cell analysis of the synovium and infrapatellar fat pad identifies key pathogenic genes and drug targets in osteoarthritis.International journal of clinical and experimental pathology · 2026Article
- TSC22D1 is a newly identified inhibitor of insulin secretion in pancreatic beta cells.The FEBS journal · 2025Article
- Article
- Heat shock protein DNAJA2 controls insulin signaling and glucose homeostasis by preventing spontaneous insulin receptor endocytosis.Nature communications · 2025Article
- Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes.Nature communications · 2025Article
- ELAPOR1 is a copper-dependent tethering factor driving proacrosomal vesicle fusion during acrosome biogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Regulation and function of insulin and insulin-like growth factor receptor signalling.Nature reviews. Molecular cell biology · 2025Review
- Inceptor binds to and directs insulin towards lysosomal degradation in β cells.Nature metabolism · 2024Article
- Rethinking Diabetes from the Perspective of Diverse Insulin Actions in Various Organs.JMA journal · 2024Review
Corrections and comments
- Commented on by
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- Erratum issued
Authors and funding
28 authors at 4 institutions in 1 country.
Ansarullah *Institute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany.
Chirag Jain *Institute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany.
Fataneh Fathi Far *Institute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany.
Sarah Homberg *Institute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany.
Katharina Wißmiller *Institute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-0224-7563
Felizitas Gräfin von Hahn *Institute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany.
Aurelia RaducanuInstitute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany.
Silvia SchirgeInstitute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany.
Michael SterrInstitute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany.
Sara BilekovaInstitute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-6699-1386
Johanna SiehlerInstitute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany.
Julius WienerHelmholtz Pioneer Campus, Helmholtz Center Munich, Neuherberg, Germany.
Lena OppenländerInstitute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany.
Amir MorshediInstitute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany.
Aimée Bastidas-PonceInstitute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany.
Gustav ColldenInstitute of Diabetes and Obesity, Helmholtz Center Munich, Neuherberg, Germany.
Martin IrmlerGerman Center for Diabetes Research (DZD), Neuherberg, Germany.ORCID http://orcid.org/0000-0003-3169-479X
Johannes BeckersGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Annette FeuchtingerCore Facility Pathology and Tissue Analytics, Helmholtz Center Munich, Neuherberg, Germany.
Michal GrzybekGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Christin AhlbrechtGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Regina FeederleMonoclonal Antibody Core Facility, Helmholtz Center Munich, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-3981-367X
Oliver PlettenburgGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Timo D MüllerGerman Center for Diabetes Research (DZD), Neuherberg, Germany.ORCID http://orcid.org/0000-0002-0624-9339
Matthias MeierHelmholtz Pioneer Campus, Helmholtz Center Munich, Neuherberg, Germany.
Matthias H TschöpGerman Center for Diabetes Research (DZD), Neuherberg, Germany.ORCID http://orcid.org/0000-0002-4744-371X
Ünal CoskunGerman Center for Diabetes Research (DZD), Neuherberg, Germany.ORCID http://orcid.org/0000-0003-4375-3144
Heiko LickertInstitute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany. heiko.lickert@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0002-4597-8825
Helmholtz Zentrum München · DEDeutsches Diabetes-Zentrum e.V. · DELeibniz University Hannover · DEUniversity of Freiburg · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistance to insulin and insulin-like growth factor 1 (IGF1) in pancreatic β-cells causes overt diabetes in mice; thus, therapies that sensitize β-cells to insulin may protect patients with diabetes against β-cell failure
Indexed as
Signal TransductionAnimalsBlood GlucoseCell LineCell ProliferationCell SizeClathrinEndocrine CellsEndocytosisEndoplasmic ReticulumGlucose Tolerance TestGolgi ApparatusHumansInsulinInsulin AntagonistsInsulin-Like Growth Factor IBlood GlucoseClathrinELAPOR1 protein, humanInsulinInsulin AntagonistsInsulin-Like Growth Factor IMembrane ProteinsNeoplasm ProteinsReceptor, InsulinTamoxifen
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.