ArticleNature protocols2021
Synthesis of N-heterocyclic carbene gold(I) complexes.
Article in Nature protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- IPr*Dalton transactions (Cambridge, England : 2003) · 2026Article
- Carbene formation as a mechanism for efficient intracellular uptake of cationic antimicrobial carbon acid polymers.Nature communications · 2025Article
- Reversible Decarbonylation of a Metal Phosphaketene.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- IPr*Inorganic chemistry · 2025Article
- Investigation on Gold Dissolution Performance and Mechanism in Imidazolium Cyanate Ionic Liquids.Molecules (Basel, Switzerland) · 2024Article
- Understanding the Surprising Oxidation Chemistry of Au-OH Complexes.Chemphyschem : a European journal of chemical physics and physical chemistry · 2023Article
- "Dynamical Docking" of Cyclic Dinuclear Au(I) Bis-N-heterocyclic Complexes Facilitates Their Binding to G-Quadruplexes.Inorganic chemistry · 2022Article
- Cationic Gold(II) Complexes: Experimental and Theoretical Study.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Realizing 1,1-Dehydration of Secondary Alcohols to Carbenes: Pyrrolidin-2-ols as a Source of Cyclic (Alkyl)(Amino)Carbenes.Angewandte Chemie (International ed. in English) · 2022Article
- Boosting Gold(I) Catalysis via Weak Interactions: New Fine-Tunable Impy Ligands.ACS organic & inorganic Au · 2022Article
- Crystal structures of the gold NHC complex bis-(4-bromo-1,3-di-ethyl-imidazol-2-yl-idene)gold(I) iodide and its 1:1 adduct withActa crystallographica. Section E, Crystallographic communications · 2021Article
- Gold(I) and Gold(III) N-Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase.ChemMedChem · 2021Article
- Au⋅⋅⋅H-C Hydrogen Bonds as Design Principle in Gold(I) Catalysis.Angewandte Chemie (International ed. in English) · 2021Article
- Simple Synthetic Routes to Carbene-M-Amido (M=Cu, Ag, Au) Complexes for Luminescence and Photocatalysis Applications.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Evaluation of Ruthenium(II)Molecules (Basel, Switzerland) · 2021Article
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4 authors.
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Abstract
N-heterocyclic carbene gold(I) chloride and hydroxide complexes are regularly used as synthons to access various oxygen-, nitrogen- or carbon-bound gold complexes. They are also widely employed as efficient catalysts in addition reactions of hydroelements to unsaturated bonds and in several rearrangement and decarboxylation protocols. Here we describe the multigram synthesis of the most common mononuclear N-heterocyclic carbene gold(I) chloride complexes bearing the N,N'-bis-(2,4,6-trimethylphenyl)imidazol-2-ylidene (IMes), N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (IPr) and N,N'-bis(2,6-bis(diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene (IPr*) ligands. Their synthesis is achieved through the straightforward and practical weak base approach in a total time of 4-5 h. This straightforward methodology is conducted under air and possesses considerable advantages over alternative routes, such as the use of a sustainable reaction solvent, minimal amounts of a mild base and commercially available or easily obtained starting materials. Additionally, we describe the synthesis of the mononuclear gold(I) hydroxide complex bearing the IPr ligand, using the state-of-the-art method requiring 24 h. Finally, the improved synthesis of the dinuclear gold(I) hydroxide complex [{Au(IPr)}
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