Evidence map›Paper›PMID 33504955›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021

Augmentation therapy with minocycline in treatment-resistant depression patients with low-grade peripheral inflammation: results from a double-blind randomised clinical trial.

Maria Antonietta Nettis, Giulia Lombardo, Caitlin Hastings, Zuzanna Zajkowska, Nicole Mariani, Naghmeh Nikkheslat, Courtney Worrell, Daniela Enache, Anna McLaughlin, Melisa Kose and 6 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 8 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 8 syntheses or guidelines pooled it, 223 citations in OpenAlex.

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  8. BrainFrontiers in immunology · 2021
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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 1 institution in 2 countries.

Maria Antonietta NettisKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK.ORCID http://orcid.org/0000-0002-5401-8391
Giulia LombardoKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Caitlin HastingsKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Zuzanna ZajkowskaKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK.ORCID http://orcid.org/0000-0002-5214-305X
Nicole MarianiKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Naghmeh NikkheslatKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Courtney WorrellKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Daniela EnacheKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Anna McLaughlinKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Melisa KoseKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Luca SforziniKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Anna BogdanovaKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Anthony CleareKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK.
Allan H YoungKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK.ORCID http://orcid.org/0000-0003-2291-6952
Carmine M ParianteKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK.ORCID http://orcid.org/0000-0002-9132-5091
Valeria MondelliKing's College London, Institute of Psychiatry Psychology and Neuroscience, Department of Psychological Medicine, London, UK. valeria.mondelli@kcl.ac.uk.ORCID http://orcid.org/0000-0001-8690-6839
King's College London · GB

Funding

Department of HealthMedical Research Council G108/603Medical Research Council MR/J002739/1Medical Research Council MR/N029488/1MRF_ MRF-160-0005-ELP-MONDEWellcome Trust
6 · The paper itself

Abstract

This study aimed to investigate the role of baseline levels of peripheral inflammation when testing the efficacy of antidepressant augmentation with minocycline in patients with treatment-resistant depression. We conducted a 4-week, placebo-controlled, randomised clinical trial of minocycline (200 mg/day) added to antidepressant treatment in 39 patients selected for elevated levels of serum C-reactive protein (CRP ≥ 1 mg/L), n = 18 randomised to minocycline (M) and n = 21 to placebo (P). The main outcome was the change in Hamilton Depression Rating Scale (HAM-D-17) score from baseline to week 4, expressed both as mean and as full or partial response, in the overall sample and after further stratification for baseline CRP≥3 mg/L. Secondary outcomes included changes in other clinical and inflammatory measures. Changes in HAM-D-17 scores and the proportion of partial responders did not differ between study arms. After stratification for CRP levels <3 mg/L (CRP

Indexed as

Depressive Disorder, Treatment-ResistantMinocyclineDepressionDouble-Blind MethodHumansInflammationTreatment OutcomeMinocycline

Identifiers

PMID33504955
PMCPMC8096832
OpenAlexW3119172333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.