ArticleProstate cancer and prostatic diseases2021
Focal therapy compared to radical prostatectomy for non-metastatic prostate cancer: a propensity score-matched study.
Article in Prostate cancer and prostatic diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Evaluating less-invasive strategies for localized prostate cancer: a comparative meta-analysis on high-intensity focused ultrasound versus radical prostatectomy.International urology and nephrology · 2026Pooled it
- Partial prostatectomy in prostate cancer: a systematic review of current evidence.Clinics (Sao Paulo, Brazil)Pooled it
- Genomic Biomarker for Prostate Cancer Focal Therapy: Post Hoc Assessment of a Phase II Clinical Trial.JCO precision oncology · 2025Trial
- Cancer-specific mortality in high-risk or very high-risk prostate cancer patients treated with cryotherapy vs. external beam radiation therapy.World journal of urology · 2026Article
- Review
- Prostate specific membrane antigen focal ablation imaging (PSMA-FAB).Prostate cancer and prostatic diseases · 2026Review
- Oncological and functional outcomes of focal irreversible electroporation for localised prostate cancer: a single institution series of 171 cases.Prostate cancer and prostatic diseases · 2026Article
- MR Imaging/Ultrasound Fusion-Guided Biopsy and Primary Focal Therapy for Localized Prostate Cancer.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Review
- 10-year oncological outcomes of EBRT versus HIFU for stage II prostate cancer: a multicenter Chang Gung research database (CGRD) study with inverse-probability-of-treatment weighting (IPTW) analysis.International urology and nephrology · 2026Article
- Hemigland cryoablation versus high-intensity focused ultrasound for localized prostate cancer: a propensity-weighted comparison of functional and oncologic outcomes.World journal of urology · 2026Article
- MRI performance to identify clinically significant prostate cancer following focal cryo-ablation.BJUI compass · 2025Article
- Emerging role of the neurovascular structure-adjacent frozen-section examination technique in robot-assisted radical prostatectomy amidst the diversification of treatment strategies for localized prostate cancer.Translational andrology and urology · 2025Article
- Focal therapy for prostate cancer in Ireland: addressing the national objective and subjective needs.Irish journal of medical science · 2025Article
- Review
- Treatment Intensification Prior to Radical Prostatectomy for Clinically Localized Prostate Cancer.Cancers · 2025Review
- Focal therapy for prostate cancer.Abdominal radiology (New York) · 2025Review
- Focal therapy in prostate cancer: Development, application and outcomes in the United Kingdom.BJUI compass · 2025Review
- Oncological effects and complications of salvage cryotherapy for radio-recurrent prostate cancer: a systematic review and meta-analysis.Frontiers in oncology · 2025Review
- The state of focal therapy in the treatment of prostate cancer: the university of California collaborative (UC-Squared) consensus statement.Prostate cancer and prostatic diseases · 2024Article
- Win ratio analysis of short-term clinical outcomes of focal therapy and robot-assisted radical prostatectomy for the patients with localized prostate cancer.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
31 authors at 17 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFocal therapy (FT) ablates areas of prostate cancer rather than treating the whole gland. We compared oncological outcomes of FT to radical prostatectomy (RP).
methodsUsing prospective multicentre databases of 761 FT and 572 RP cases (November/2005-September/2018), patients with PSA < 20 ng/ml, Gleason </= 4 + 3 and stage </= T2c were 1-1 propensity score-matched for treatment year, age, PSA, Gleason, T-stage, cancer core length and use of neoadjuvant hormones. FT included 1-2 sessions. Primary outcome was failure-free survival (FFS) defined by need for salvage local or systemic therapy or metastases. Differences in FFS were determined using Kaplan-Meier analysis with log-rank test.
results335 radical prostatectomy and 501 focal therapy patients were eligible for matching. For focal therapy, 420 had HIFU and 81 cryotherapy. Cryotherapy was used predominantly for anterior cancer. After matching, 246 RP and 246 FT cases were identified. For radical prostatectomy, mean (SD) age was 63.4 (5.6) years, median (IQR) PSA 7.9 g/ml (6-10) and median (IQR) follow-up 64 (30-89) months. For focal therapy, these were 63.3 (6.9) years, 7.9 ng/ml (5.5-10.6) and 49 [34-67] months, respectively. At 3, 5 and 8 years, FFS (95%CI) was 86% (81-91%), 82% (77-88%) and 79% (73-86%) for radical prostatectomy compared to 91% (87-95%), 86% (81-92%) and 83% (76-90%) following focal therapy (p = 0.12).
conclusionsIn patients with non-metastatic low- intermediate prostate cancer, oncological outcomes over 8 years were similar between focal therapy and radical prostatectomy.
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