ArticleScientific reports2021
Predictors of negative first SARS-CoV-2 RT-PCR despite final diagnosis of COVID-19 and association with outcome.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 30 citations in OpenAlex.
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- Development and external validation of a prediction model for the transition from mild to moderate or severe form of COVID-19.European radiology · 2023Article
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- Correlations between Cytokine Levels, Liver Function Markers, and Neuropilin-1 Expression in Patients with COVID-19.Vaccines · 2022Article
- Nanoplasmonic biosensor for rapid detection of multiple viral variants in human serum.Sensors and actuators. B, Chemical · 2022Article
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- ERS International Congress 2021: highlights from the Respiratory Clinical Care and Physiology Assembly.ERJ open research · 2022Review
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- Lateral Flow Immunoassay of SARS-CoV-2 Antigen with SERS-Based Registration: Development and Comparison with Traditional Immunoassays.Biosensors · 2021Article
- Comparison of clinical, laboratory and radiological features in confirmed and unconfirmed COVID-19 patients.Future microbiology · 2021Article
- SARS-CoV-2 rapid antigen testing in the healthcare sector: A clinical prediction model for identifying false negative results.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Article
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- Negative antigen RDT and RT-PCR results do not rule out COVID-19 if clinical suspicion is strong.The Lancet. Infectious diseases · 2021Article
- Clinical characteristics and factors associated with hospital admission or death in 43 103 adult outpatients with coronavirus disease 2019 managed with the Covidom telesurveillance solution: a prospective cohort study.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021Article
- Evaluation of Cytokines as Robust Diagnostic Biomarkers for COVID-19 Detection.Journal of personalized medicine · 2021Article
- Diagnostic Accuracy of a New Antigen Test for SARS-CoV-2 Detection.International journal of environmental research and public health · 2021Article
- RT- PCR testing of upper respiratory tract samples for diagnosis of SARS-CoV-2: Between justification and overestimation, a multi-center international study.Travel medicine and infectious diseaseArticle
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Authors and funding
12 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reverse transcriptase-polymerase chain reaction (RT-PCR) testing is an important tool for diagnosing coronavirus disease 2019 (COVID-19). However, performance concerns have emerged recently, notably regarding sensitivity. We hypothesized that the clinical, biological, and radiological characteristics of patients with a false-negative first RT-PCR test and a final diagnosis of COVID-19 might differ from those of patients with a positive first RT-PCR test. We conducted a multicenter matched case-control study in COVID-19 patients. Patients with a negative first RT-PCR test were matched to patients with a positive first RT-PCR test on age, sex, and initial admission unit (ward or intensive care). We included 80 cases and 80 controls between March 30, and June 22, 2020. Neither mortality at hospital discharge nor hospital stay length differed between the two groups (P = 0.80 and P = 0.54, respectively). By multivariate analysis, two factors were independently associated with a lower risk of a first false-negative test, namely, headache (adjusted OR [aOR], 0.07; 95% confidence interval [95% CI], 0.01-0.49]; P = 0.007) and fatigue/malaise (aOR, 0.16; 95% CI, 0.03-0.81; P = 0.027); two other factors were independently associated with a higher risk of a first false-negative test, namely, platelets > 207·10
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