Evidence map›Paper›PMID 33504854›Full record

ArticleScientific reports2021

Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk.

Arun Kumar, Mohammad Ali, Ranjit Kumar, Mukesh Kumar, Prity Sagar, Ritu Kumari Pandey, Vivek Akhouri, Vikas Kumar, Gautam Anand, Pintoo Kumar Niraj and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
15.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 175 citations in OpenAlex.

  1. Carcinogenic effect of arsenic in digestive cancers: a systematic review.Environmental health : a global access science source · 2023
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Metal Concentrations in Edible Leafy Vegetables and Their Potential Risk to Human Health.International journal of environmental research and public health · 2026
    Article
  8. Article
  9. Article
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  11. Grain arsenic accumulation is independent of agronomic traits in rice under field conditions.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. [Assessment of Dietary Arsenic Exposure Levels and the Associated Health Risks in Chongqing City, China].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Arun KumarMahavir Cancer Sansthan and Research Centre, Patna, Bihar, 801505, India. drarunk31@gmail.com.ORCID http://orcid.org/0000-0002-8946-5909
Mohammad AliMahavir Cancer Sansthan and Research Centre, Patna, Bihar, 801505, India.
Ranjit KumarDepartment of Animal Sciences, Central University of Himachal Pradesh, Kangra, Himachal Pradesh, India.
Mukesh KumarMahavir Cancer Sansthan and Research Centre, Patna, Bihar, 801505, India.
Prity SagarMahavir Cancer Sansthan and Research Centre, Patna, Bihar, 801505, India.
Ritu Kumari PandeyMahavir Cancer Sansthan and Research Centre, Patna, Bihar, 801505, India.
Vivek AkhouriMahavir Cancer Sansthan and Research Centre, Patna, Bihar, 801505, India.
Vikas KumarMahavir Cancer Sansthan and Research Centre, Patna, Bihar, 801505, India.
Gautam AnandMahavir Cancer Sansthan and Research Centre, Patna, Bihar, 801505, India.
Pintoo Kumar NirajMahavir Cancer Sansthan and Research Centre, Patna, Bihar, 801505, India.
Rita RaniMahavir Cancer Sansthan and Research Centre, Patna, Bihar, 801505, India.
Santosh KumarDepartment of Applied Geoscience and Engineering, Delft University of Technology, Delft, The Netherlands.
Dhruv KumarAmity Institute of Molecular Medicine and Stem Cell Research, Amity University Uttar Pradesh, Noida, India.
Akhouri BishwapriyaGeological Survey of India, Patna, Bihar, India.
Ashok Kumar GhoshMahavir Cancer Sansthan and Research Centre, Patna, Bihar, 801505, India.
Mahavir Cancer Institute and Research Centre · INAmity University · INCentral University of Himachal Pradesh · INDelft University of Technology · NLGeological Survey of India · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reportedly, 300 million people worldwide are affected by the consumption of arsenic contaminated groundwater. India prominently figures amongst them and the state of Bihar has shown an upsurge in cases affected by arsenic poisoning. Escalated arsenic content in blood, leaves 1 in every 100 human being highly vulnerable to being affected by the disease. Uncontrolled intake may lead to skin, kidney, liver, bladder, or lung related cancer but even indirect forms of cancer are showing up on a regular basis with abnormal arsenic levels as the probable cause. But despite the apparent relation, the etiology has not been understood clearly. Blood samples of 2000 confirmed cancer patients were collected from pathology department of our institute. For cross-sectional design, 200 blood samples of subjects free from cancer from arsenic free pockets of Patna urban agglomeration, were collected. Blood arsenic levels in carcinoma patients as compared to sarcomas, lymphomas and leukemia were found to be higher. The geospatial map correlates the blood arsenic with cancer types and the demographic area of Gangetic plains. Most of the cancer patients with high blood arsenic concentration were from the districts near the river Ganges. The raised blood arsenic concentration in the 2000 cancer patients strongly correlates the relationship of arsenic with cancer especially the carcinoma type which is more vulnerable. The average arsenic concentration in blood of the cancer patients in the Gangetic plains denotes the significant role of arsenic which is present in endemic proportions. Thus, the study significantly correlates and advocates a strong relation of the deleterious element with the disease. It also underlines the need to address the problem by deciphering the root cause of the elevated cancer incidences in the Gangetic basin of Bihar and its association with arsenic poisoning.

Indexed as

AdultAgedArsenicArsenic PoisoningBiomarkersCase-Control StudiesEnvironmental ExposureFemaleGeography, MedicalHumansIndiaMaleMiddle AgedNeoplasmsRisk AssessmentRisk FactorsArsenicBiomarkers

Identifiers

PMID33504854
PMCPMC7841152
OpenAlexW3126042409

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.