Evidence map›Paper›PMID 33504837›Full record

ArticleScientific reports2021

Salicylic diamines selectively eliminate residual undifferentiated cells from pluripotent stem cell-derived cardiomyocyte preparations.

Karsten Burkert, Hadiseh Taheri, Sarkawt Hamad, Matteo Oliverio, Gabriel Peinkofer, Jan-Wilhelm Kornfeld, Wacharee Harnying, Kurt Pfannkuche, Jürgen Hescheler, Albrecht Berkessel and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Karsten BurkertCenter for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany.
Hadiseh TaheriCenter for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany.
Sarkawt HamadCenter for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany.
Matteo OliverioMax Planck Institute for Metabolism Research, Cologne, Germany.
Gabriel PeinkoferCenter for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany.
Jan-Wilhelm KornfeldMax Planck Institute for Metabolism Research, Cologne, Germany.ORCID 0000-0002-6802-4442
Wacharee HarnyingDepartment of Chemistry, Organic Chemistry, University of Cologne, Cologne, Germany.
Kurt PfannkucheCenter for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany.
Jürgen HeschelerCenter for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany.
Albrecht BerkesselDepartment of Chemistry, Organic Chemistry, University of Cologne, Cologne, Germany. berkessel@uni-koeln.de.ORCID 0000-0003-0470-7428
Tomo ŠarićCenter for Physiology and Pathophysiology, Institute for Neurophysiology, Medical Faculty, University of Cologne, Cologne, Germany. tomo.saric@uni-koeln.de.ORCID 0000-0001-8344-1095
University of Cologne · DEMax Planck Institute for Metabolism Research · DETH Köln - University of Applied Sciences · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical translation of pluripotent stem cell (PSC) derivatives is hindered by the tumorigenic risk from residual undifferentiated cells. Here, we identified salicylic diamines as potent agents exhibiting toxicity to murine and human PSCs but not to cardiomyocytes (CMs) derived from them. Half maximal inhibitory concentrations (IC

Indexed as

AnimalsCell DifferentiationCell SurvivalDiaminesDose-Response Relationship, DrugHumansInduced Pluripotent Stem CellsMiceMolecular StructureMyocytes, CardiacOxygen ConsumptionTeratomaDiamines

Identifiers

PMID33504837
PMCPMC7841182
OpenAlexW3124165904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.