ArticleScientific reports2021
Epithelial and stromal remodelling following femtosecond laser-assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Lenticule addition keratoplasty for the treatment of keratoconus: A systematic review and critical considerations.Indian journal of ophthalmology · 2024Pooled it
- Preservation and Reuse of KLEx Lenticules: From Biobanking to Therapeutic and Refractive Innovations.Bioengineering (Basel, Switzerland) · 2026Review
- Human stromal corneal lenticule implantation for refractory full-thickness macular holes: surgical technique and preliminary outcomes.Eye (London, England) · 2026Article
- Ex Vivo Assessment of Excimer Laser-Assisted Lenticule Customization.Translational vision science & technology · 2026Article
- Deep-stromal implantation of a double-crosslinked bioengineered porcine collagen implant (BPCDX) in advanced keratoconus: a 12-month study of corneal remodeling and visual outcomes.Scientific reports · 2026Article
- [New tissue-additive procedures to improve vision in keratoconus].Die Ophthalmologie · 2026Review
- Advancements and Innovations in Keratoconus Management: A Review of Current Practices.Journal of clinical medicine · 2025Review
- Combined femtosecond intrastromal lenticular implantation and corneal crosslinking to treat advanced keratoconus: a 6-month observation including epithelial remodeling.BMC ophthalmology · 2025Article
- Randomized controlled trial on corneal denervation, neuroinflammation and ocular surface in corneal lenticule extraction for advanced refractive correction (CLEAR) and small incision lenticule extraction (SMILE).Eye and vision (London, England) · 2025Article
- Corneal surface changes after stromal lenticule addition keratoplasty combined with cross-linking for severe keratoconus.International journal of ophthalmology · 2025Article
- Long-term results of allogenic corneal lenticule of hyperopic SMILE for post-LASIK ectasia.iScience · 2024Article
- Ex Vivo Lenticule Customization for Stromal Lenticule Addition Keratoplasty.Investigative ophthalmology & visual science · 2024Article
- Stromal lenticule addition keratoplasty with corneal crosslinking for corneal ectasia secondary to FS-LASIK: a case series.International journal of ophthalmology · 2024Article
- Corneal Epithelial Thickness Mapping: A Major Review.Journal of ophthalmology · 2024Review
- Allogenic Lenticular Implantation for Correction of Refractive Error and Ectasia: Narrative Review.Ophthalmology and therapy · 2023Review
- Changes in the posterior corneal surface after femtosecond laser-assisted lenticule intrastromal keratoplasty (LIKE) performed into a pocket (SMI-LIKE) or under a flap (FS-LIKE).Eye and vision (London, England) · 2023Article
- Management of keratoconus: an updated review.Frontiers in medicine · 2023Review
- Incisional surface quality of electron-beam irradiated cornea-extracted lenticule for stromal keratophakia: high nJ-energy vs. low nJ-energy femtosecond laser.Frontiers in medicine · 2023Article
- Update of Research Progress on Small Incision Lenticule Extraction (SMILE) Lenticule Reuse.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- Effect of corneal stromal lenticule customization on neurite distribution and excitatory property.Journal of advanced research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to evaluate corneal epithelium and stromal remodelling with anterior segment optical coherence tomography in patients who have undergone stromal lenticule addition keratoplasty (SLAK) for advanced keratoconus. This was a prospective non-comparative observational study. Fifteen eyes of 15 patients with advanced keratoconus underwent implantation with a cadaveric, donor negative meniscus-shaped intrastromal lenticule, produced with a femtosecond laser, into a stromal pocket dissected in the recipient cornea at a depth of 120 μm. Simulated keratometry, central corneal thickness (CTT), corneal thinnest point (CTP), central epithelial thickness (CET), central and peripheral lenticule thickness, anterior and posterior stromal thickness were measured. Regional central corneal epithelial thickness (CET) and variations in the inner annular area (IAT) and outer annular area (OAT) were also analysed. All parameters were measured preoperatively and 1, 3, and 6 months postoperatively. The average anterior Sim-k decreased from 59.63 ± 7.58 preoperatively to 57.19 ± 6.33 D 6 months postoperatively. CCT, CTP, CET, and OAT increased and IAT decreased significantly after 1 month. All parameters appeared unchanged at 6-months except that of OAT that further increased. Lenticule thickness was stable. In conclusion we observed that SLAK reshapes the cornea by central flattening with stromal thickening and epithelial thickness restoration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.