ArticleNature communications2021
IDH1 mutations induce organelle defects via dysregulated phospholipids.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
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Who cites it
49 citing papers in PubMed, 74 citations in OpenAlex.
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- Metabolic Landscape and Emerging Therapeutic Potential in Pediatric and Adult Gliomas.International journal of molecular sciences · 2026Review
- Exploring Lipid Metabolic Reprogramming: Mechanistic Insights and Implications for Tumor Radiotherapy.International journal of biological sciences · 2026Review
- Glioblastoma-enriched glycosphingolipids modulate the function of human iNKT cells.Neuro-oncology · 2025Article
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- Lipidomics and temporal-spatial distribution of organelle lipid.Journal of biological methods · 2025Review
- Raman-based machine-learning platform reveals unique metabolic differences between IDHmut and IDHwt glioma.Neuro-oncology · 2024Article
- Preparation and Preclinical Evaluation ofMolecules (Basel, Switzerland) · 2024Article
- Challenges of Spatially Resolved Metabolism in Cancer Research.Metabolites · 2024Review
- Illuminating the dark space of neutral glycosphingolipidome by selective enrichment and profiling at multi-structural levels.Nature communications · 2024Article
- IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma.Biological research · 2024Article
- Valproic acid targets IDH1 mutants through alteration of lipid metabolism.npj metabolic health and disease · 2024Article
- Advances in regulation and function of stearoyl-CoA desaturase 1 in cancer, from bench to bed.Science China. Life sciences · 2023Review
- Inferring mitochondrial and cytosolic metabolism by coupling isotope tracing and deconvolution.Nature communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 5 institutions in 2 countries.
Adrian Lita *Neuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0115-6077
Artem Pliss *Institute for Lasers, Photonics and Biophotonics, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Andrey KuzminInstitute for Lasers, Photonics and Biophotonics, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Tomohiro YamasakiNeuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-9858-9049
Lumin ZhangNeuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA.
Tyrone DowdyNeuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-6833-8089
Christina BurksElectron Microscopy Laboratory, Frederick National Laboratory for Cancer Research, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA.
Natalia de ValElectron Microscopy Laboratory, Frederick National Laboratory for Cancer Research, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA.
Orieta CelikuNeuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0500-1032
Victor Ruiz-RodadoNeuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA.
Elena-Raluca NicoliUndiagnosed Diseases Program, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.
Michael KruhlakLaboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, 20892, USA.
Thorkell AndressonProtein Characterization Laboratory of the Cancer Research Technology Program (CRTP), National Cancer Institute, Frederick, MD, 21702, USA.
Sudipto DasProtein Characterization Laboratory of the Cancer Research Technology Program (CRTP), National Cancer Institute, Frederick, MD, 21702, USA.
Chunzhang YangNeuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA.
Rebecca SchmittInstitute for Lasers, Photonics and Biophotonics, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Christel Herold-MendeDivision of Neurosurgical Research, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
Mark R GilbertNeuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA.
Paras N PrasadInstitute for Lasers, Photonics and Biophotonics, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Mioara LarionNeuro-Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA. mioara.larion@nih.gov.ORCID 0000-0002-7016-9587
National Institutes of Health · USUniversity at Buffalo, State University of New York · USCancer Research Center · USFrederick National Laboratory for Cancer Research · USHeidelberg University · DE
Funding
CCR Microscopy CoreZICBC010858 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KRUHLAK, MICHAEL · 2009 to 2025
$14.8MNrf2-goverened metabolic reprogram in IDH1-mutated gliomaZIABC011761 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YANG, CHUN ZHANG · 2017 to 2025
$3.4MDevelop RAMAN imaging to visualize metabolism in cell lines and tissueZIABC011711 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LARION, MIOARA · 2016 to 2025
$3.3MMetabolite profiling of patients blood, urine, cerebrospinal fluid and tissueZIABC011709 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LARION, MIOARA · 2016 to 2025
$1.6MNovel single cell assay for quantitative analysis of cell heterogeneity by noninvasive probing of molecular composition of specific organelles in individual cellsR44GM116193 · NIGMS · ADVANCED CYTOMETRY INSTRUMENTATION SYS · PI KUZMIN, ANDREY · 2017 to 2018
$1.2MNIGMS NIH HHS R44 GM116193
Abstract
Infiltrating gliomas are devastating and incurable tumors. Amongst all gliomas, those harboring a mutation in isocitrate dehydrogenase 1 mutation (IDH1
Indexed as
Cell Line, TumorEndoplasmic ReticulumGlioblastomaGolgi ApparatusHumansIsocitrate DehydrogenaseModels, BiologicalMutationOligodendrogliomaOrganellesPhospholipidsStearoyl-CoA DesaturaseIDH1 protein, humanIsocitrate DehydrogenasePhospholipidsSCD1 protein, humanStearoyl-CoA Desaturase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.