Evidence map›Paper›PMID 33504470›Full record

ArticleBiology open2021

Keegan M Bush, Kara R Barber, Jade A Martinez, Shao-Jun Tang, Yogesh P Wairkar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Keegan M BushNeuroscience Graduate Program, University of. Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0003-3237-9134
Kara R BarberNeuroscience Graduate Program, University of. Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-4042-9886
Jade A MartinezMitchell Center for Neurodegenerative Diseases, Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Shao-Jun TangNeuroscience Graduate Program, University of. Texas Medical Branch, Galveston, TX 77555, USA shtang@utmb.edu yowairka@utmb.edu.ORCID 0000-0002-6076-5481
Yogesh P WairkarNeuroscience Graduate Program, University of. Texas Medical Branch, Galveston, TX 77555, USA shtang@utmb.edu yowairka@utmb.edu.ORCID 0000-0002-8960-9781

Funding

Wnt signaling in glial activation during HIV-associated chronic pain pathogenesisR01NS079166 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI TANG, SHAO-JUN · 2012 to 2021
$5.5M
Cooperative mechanisms of HIV and opiods in pain pathogenisisR01DA050530 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CHUNG, JIN M, TANG, SHAO-JUN · 2019 to 2023
$3.2M
Antiretroviral Therapy and Neuroinflammation in the CNSR01NS095747 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CHUNG, JIN M · 2016 to 2020
$2.6M
Interplay of HIV-1 gp120 and opioids in astrocyte activationR01DA036165 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI TANG, SHAO-JUN · 2013 to 2017
$1.9M
Mechanisms of Synapse Vulnerability in Neurodegenerative DisordersR56NS105681 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WAIRKAR, YOGESH P · 2019 to 2019
$591k
NIDA NIH HHS R01 DA036165NIDA NIH HHS R01 DA050530NINDS NIH HHS R01 NS079166NINDS NIH HHS R01 NS095747NINDS NIH HHS R56 NS105681
6 · The paper itself

Abstract

The success of antiretroviral therapy (ART) has improved the survival of HIV-infected patients significantly. However, significant numbers of patients on ART whose HIV disease is well controlled show peripheral sensory neuropathy (PSN), suggesting that ART may cause PSN. Although the nucleoside reverse transcriptase inhibitors (NRTIs), one of the vital components of ART, are thought to contribute to PSN, the mechanisms underlying the PSN induced by NRTIs are unclear. In this study, we developed a

Indexed as

AnimalsAnti-HIV AgentsAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveDisease Models, AnimalDrosophilaHIV InfectionsHumansNociceptive PainPeripheral Nervous System DiseasesSensory Receptor CellsAnti-HIV AgentsAnti-Retroviral AgentsDendritesHIVNRTIStabilitySynapse

Identifiers

PMID33504470
PMCPMC7860131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.