Evidence map›Paper›PMID 33504329›Full record

Trial reportBMC anesthesiology2021

Effects of sevoflurane and propofol on the optic nerve sheath diameter in patients undergoing laparoscopic gynecological surgery: a randomized controlled clinical studies.

Weilian Geng, Changxing Chen, Xingfeng Sun, Shaoqiang Huang

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03498235 early_phase1unknown statusnot on this map

Randomized,Double-Blind Trial A Comparative Analysis of the Effects of Sevoflurane and Propofol on Optic Nerve Sheath Diameter During Steep Trendelenburg Position and Pneumoperitoneum for Laparoscopic Gynecologic Surgery

TypeinterventionalSponsorObstetrics & Gynecology Hospital of Fudan UniversityRan2018 to 2020Enrolled110ConditionsLaparoscopic Gynecologic SurgeryArmsSevoflurane, Propofol
NCT07155109 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Effects of Different Intraperitoneal Pressures on Optic Nerve Sheath Diameter in Laparoscopic Gyneco-oncologic Surgeries

TypeinterventionalSponsorDiskapi Yildirim Beyazit Education and Research HospitalRan2025 to 2025Enrolled100ConditionsIntracranial Pressure Increase, Abdominal Pain, Head PainArmsLow pressure group, Normal pressure group
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Observational
  6. Observational
  7. Article
  8. Article
  9. Observational
  10. Review
  11. Effect of Percutaneous Tracheostomy on Optic Nerve Sheath Diameter (TONS Trial).Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022
    Article
  12. Reply to Letter to Editor: Effect of Percutaneous Tracheostomy on Optic Nerve Sheath Diameter [TONS Trial].Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Weilian Geng *Department of Anesthesia, Obstetrics and Gynecology Hospital of Fudan University, No.128, Shenyang RD, Yangpu district, Shanghai, 200090, China.
Changxing Chen *Department of Emergency and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xingfeng SunDepartment of Anesthesia, Obstetrics and Gynecology Hospital of Fudan University, No.128, Shenyang RD, Yangpu district, Shanghai, 200090, China.
Shaoqiang HuangDepartment of Anesthesia, Obstetrics and Gynecology Hospital of Fudan University, No.128, Shenyang RD, Yangpu district, Shanghai, 200090, China. drhuangsq@163.com.ORCID 0000-0002-0515-8099
Obstetrics and Gynecology Hospital of Fudan University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe results of studies on changes in intracranial pressure in patients undergoing laparoscopic surgery are inconsistent. Meanwhile, previous neurosurgery studies have suggested that propofol and sevoflurane have inconsistent effects on cerebral blood flow and cerebrovascular self-regulation. The purpose of this study is to compare changes in the optic nerve sheath diameter in patients undergoing laparoscopic gynecological surgery under anesthetic maintenance with propofol versus sevoflurane.

methodsThis study included 110 patients undergoing laparoscopic gynecological surgery with an estimated operative time of more than 2 h under general anesthesia. The study was a randomized controlled study. The optic nerve sheath diameter (ONSD) at various time points was measured by ultrasound, including when the patients entered the operating room (Tawake), after successful anesthesia induction and endotracheal intubation (Tinduction), when the body position was adjusted to the Trendelenburg position and the CO

resultsA significant difference in optic nerve sheath diameter was found between two groups at T

conclusionDuring laparoscopic gynecological surgery lasting more than 2 h, the optic nerve sheath diameter was slightly larger in the propofol group than that in the sevoflurane group in the first 45 min. No significant difference was observed between the two groups 1 h after surgery.

trial registrationclinicaltrials.gov, NCT03498235 . Retrospectively registered 1 March 2018. The manuscript adheres to CONSORT guidelines.

Indexed as

AdultAnesthetics, InhalationAnesthetics, IntravenousFemaleGynecologic Surgical ProceduresHumansLaparoscopyOptic NervePropofolSevofluraneAnesthetics, InhalationAnesthetics, IntravenousPropofolSevofluraneCO2 pneumoperitoneumONSD, sevofluraneOptic nerve sheath diameterPropofolTrendelenburg position

Identifiers

PMID33504329
PMCPMC7839298
OpenAlexW3119625512

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.