Evidence map›Paper›PMID 33504180›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

Perivascular Adipose Tissue Inflammation in Ischemic Heart Disease.

Celestina Mazzotta, Sanchita Basu, Adam C Gower, Shakun Karki, Melissa G Farb, Emily Sroczynski, Elaina Zizza, Anas Sarhan, Ashvin N Pande, Kenneth Walsh and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 46 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Celestina MazzottaEvans Department of Medicine and Whitaker Cardiovascular Institute (C.M., S.B., S.K., M.G.F., E.S., E.Z., A.S., A.N.P., N.G.), Boston University School of Medicine, MA.
Sanchita BasuEvans Department of Medicine and Whitaker Cardiovascular Institute (C.M., S.B., S.K., M.G.F., E.S., E.Z., A.S., A.N.P., N.G.), Boston University School of Medicine, MA.
Adam C GowerClinical and Translational Science Institute (A.C.G.), Boston University School of Medicine, MA.
Shakun Karki
Melissa G FarbEvans Department of Medicine and Whitaker Cardiovascular Institute (C.M., S.B., S.K., M.G.F., E.S., E.Z., A.S., A.N.P., N.G.), Boston University School of Medicine, MA.
Emily SroczynskiEvans Department of Medicine and Whitaker Cardiovascular Institute (C.M., S.B., S.K., M.G.F., E.S., E.Z., A.S., A.N.P., N.G.), Boston University School of Medicine, MA.
Elaina ZizzaEvans Department of Medicine and Whitaker Cardiovascular Institute (C.M., S.B., S.K., M.G.F., E.S., E.Z., A.S., A.N.P., N.G.), Boston University School of Medicine, MA.
Anas SarhanEvans Department of Medicine and Whitaker Cardiovascular Institute (C.M., S.B., S.K., M.G.F., E.S., E.Z., A.S., A.N.P., N.G.), Boston University School of Medicine, MA.
Ashvin N PandeEvans Department of Medicine and Whitaker Cardiovascular Institute (C.M., S.B., S.K., M.G.F., E.S., E.Z., A.S., A.N.P., N.G.), Boston University School of Medicine, MA.
Kenneth WalshHematovascular Biology Center and the Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville (K.W.).
Nikola DobrilovicDivision of Cardiac Surgery, Department of Surgery, Boston Medical Center, MA (N.D.).
Noyan GokceEvans Department of Medicine and Whitaker Cardiovascular Institute (C.M., S.B., S.K., M.G.F., E.S., E.Z., A.S., A.N.P., N.G.), Boston University School of Medicine, MA.
Norwegian Womens Public Health Association · NOBoston Medical Center · USAnna Needs Neuroblastoma Answers · USBoston University · USUniversity of Virginia · US

Funding

Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3M
Wnt signaling control of vascular phenotype in obesityR01HL142650 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GOKCE, NOYAN, WALSH, KENNETH · 2019 to 2023
$3.1M
Anti-Angiogenic Mechanisms in Human ObesityR01HL126141 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GOKCE, NOYAN, WALSH, KENNETH · 2015 to 2019
$2.4M
Identifying a novel regulatory pathway of vascular function in obesityR01HL140836 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GOKCE, NOYAN, PURI, VISHWAJEET · 2018 to 2021
$2.2M
Inflammatory Wnt signaling in ischemic myocardiumR01HL131006 · NHLBI · UNIVERSITY OF VIRGINIA · PI WALSH, KENNETH · 2016 to 2019
$2.1M
Determinants of obesity-associated insulin resistanceK23HL135394 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FARB, MELISSA G · 2017 to 2021
$895k
FSP27 regulation of vascular function in human obesityK01DK114897 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KARKI, SHAKUN · 2018 to 2021
$608k
NCATS NIH HHS UL1 TR001430NHLBI NIH HHS K23 HL135394NHLBI NIH HHS R01 HL126141NHLBI NIH HHS R01 HL131006NHLBI NIH HHS R01 HL140836NHLBI NIH HHS R01 HL142650NIDDK NIH HHS K01 DK114897
6 · The paper itself

Abstract

objectiveThere is growing recognition that adipose tissue-derived proatherogenic mediators contribute to obesity-related cardiovascular disease. We sought to characterize regional differences in perivascular adipose tissue (PVAT) phenotype in relation to atherosclerosis susceptibility. Approach and Results: We examined thoracic PVAT samples in 34 subjects (body mass index 32±6 kg/m

conclusionsProatherogenic mediators that originate from dysfunctional PVAT may contribute to vascular disease mechanisms in human vessels. Moreover, PVAT may adopt detrimental properties under obese conditions that play a key role in the pathophysiology of ischemic heart disease. Graphic Abstract: A graphic abstract is available for this article.

Indexed as

Adipose TissueAgedAortaAtherosclerosisChemokine CCL2FemaleGene Expression ProfilingHumansInflammationInflammation MediatorsInterleukin-1betaInterleukin-6MaleMiddle AgedMyocardial IschemiaObesityCCL2 protein, humanChemokine CCL2IL6 protein, humanInflammation MediatorsInterleukin-1betaInterleukin-6adipose tissuecoronary artery diseaseinflammationinterleukinobesity

Identifiers

PMID33504180
PMCPMC7904602
OpenAlexW3121634958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.