Evidence map›Paper›PMID 33504140›Full record

ArticleHaematologica2021

An international retrospective study for tolerability of 6-mercaptopurine on NUDT15 bi-allelic variants in children with acute lymphoblastic leukemia.

Yoichi Tanaka, Allen Eng Juh Yeoh, Takaya Moriyama, Chi-Kong Li, Ko Kudo, Yuki Arakawa, Jassada Buaboonnam, Hui Zhang, Hsi-Che Liu, Hany Ariffin and 20 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. Article
  6. Importance ofJournal of personalized medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Yoichi TanakaDivision of Medicinal Safety Science, National Institute of Health Sciences, Kawasaki.
Allen Eng Juh YeohVIVA-NUS Centre of Translational Research in Acute Leukaemia (Molecular), Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore.
Takaya MoriyamaDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Chi-Kong LiHong Kong Children's Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region.
Ko KudoDepartment of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki.
Yuki ArakawaDepartment of Hematology/Oncology, Saitama Children's Medical Center, Saitama.
Jassada BuaboonnamHematology/Oncology Division, Department of Pediatrics Faculty of Medicine, Siriraj Hospital Mahidol University.
Hui ZhangDepartment of Hematology and Oncology, Guangzhou Women and Children's Medical Center.
Hsi-Che LiuDivision of Pediatric Hematology-Oncology, Mackay Children's Hospital and Mackay Memorial Hospital, Taipei.
Hany AriffinDepartment of Paediatrics, University of Malaya Medical Centre, Kuala Lumpur.
Zhiwei ChenVIVA-NUS Centre of Translational Research in Acute Leukaemia (Molecular), Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore.
Shirley K Y KhamVIVA-NUS Centre of Translational Research in Acute Leukaemia (Molecular), Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore.
Rina NishiiDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Daisuke HasegawaDepartment of Pediatrics, St. Luke's International Hospital, Tokyo.
Junya FujimuraDepartment of Pediatrics, Juntendo University, School of Medicine, Tokyo.
Dai KeinoDepartment of Pediatrics, St. Marianna University School of Medicine Hospital, Kawasaki.
Kensuke KondohDepartment of Pediatrics, St. Marianna University School of Medicine Hospital, Kawasaki.
Atsushi SatoDepartment of Hematology and Oncology, Miyagi Children's Hospital, Sendai.
Takahiro UedaDepartment of Pediatrics, Nippon Medical School, Tokyo.
Masaki YamamotoDepartment of Pediatrics, Sapporo Medical University School of Medicine, Sapporo.
Yuichi TaneyamaDepartment of Hematology/Oncology, Chiba Children's Hospital, Chiba.
Moeko HinoDepartment of Pediatrics, Chiba University Graduate School of Medicine, Chiba.
Masatoshi TakagiDepartment of Pediatrics, Tokyo Medical and Dental University, Tokyo.
Akira OharaDepartment of Pediatrics, Toho University School of Medicine, Tokyo.
Etsuro ItoDepartment of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki.
Katsuyoshi KohHematology/Oncology Division, Department of Pediatrics Faculty of Medicine, Siriraj Hospital Mahidol University.
Hiroki HoriDepartment of Pediatrics, Mie University, Tsu, Mie.
Atsushi ManabeDepartment of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo.
Jun J YangDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Motohiro KatoDepartment of Transplantation and Cell Therapy, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan; Department of Pediatric Hematology and Oncology Research, National Center for Child Health and Development, Tokyo, Japan; Department of Pediatrics, the University of Tokyo, Tokyo. katom-tky@umin.ac.jp.

Funding

Genetics-guided Individualization of Thiopurine TherapyR01GM118578 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YANG, JUN J. · 2017 to 2020
$2.2M
NIGMS NIH HHS R01 GM118578
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MercaptopurinePrecursor Cell Lymphoblastic Leukemia-LymphomaAllelesChildHumansPyrophosphatasesRetrospective StudiesMercaptopurinePyrophosphatases

Identifiers

PMID33504140
PMCPMC8252943

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.