Evidence map›Paper›PMID 33504109›Full record

ReviewJournal of clinical medicine2021

The Association between Early-Life Gut Microbiota and Long-Term Health and Diseases.

Anujit Sarkar, Ji Youn Yoo, Samia Valeria Ozorio Dutra, Katherine H Morgan, Maureen Groer

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07309536 (Mediterranean Diet Uptake and Nutrition on Child Health, Inflammation, and Early-life Symbiosis), which is not on this map. Cited by 204 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
204citing papers in PubMed, 5 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07309536 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Mediterranean Diet Uptake and Nutrition on Child Health, Inflammation, and Early-life Symbiosis (MUNCHIES): A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of New BrunswickRan2026 to 2027Enrolled40ConditionsGut Microbiome, Body Composition, Adherence, MetabolitesArmsMediterranean Diet Nutrition Program, Standard Diet Education Program
3 · Its place in the literature

Who cites it

204 citing papers in PubMed, 5 syntheses or guidelines pooled it, 288 citations in OpenAlex.

  1. Pooled it
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  16. Clostridium Abundance and Lower Weight-for-AgeJMIR pediatrics and parenting · 2026
    Article
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  18. Review
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144 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Anujit SarkarCollege of Nursing, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0003-3170-2542
Ji Youn YooCollege of Nursing, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0001-9528-0815
Samia Valeria Ozorio DutraCollege of Nursing, University of Tennessee- Knoxville, Knoxville, TN 37916, USA.
Katherine H MorganCollege of Nursing, University of Tennessee- Knoxville, Knoxville, TN 37916, USA.
Maureen GroerCollege of Nursing, University of South Florida, Tampa, FL 33612, USA.ORCID 0000-0002-5526-2927
University of South Florida · USKnoxville College · US

Funding

The Preterm Infant Microbiome: Biological, Behavioral and Health Outcomes at 2 and 4 years of AgeR01NR015446 · NINR · UNIVERSITY OF SOUTH FLORIDA · PI GROER, MAUREEN EDITH · 2015 to 2019
$2.6M
NIH HHS R01NR015446
6 · The paper itself

Abstract

Early life gut microbiota have been increasingly recognized as major contributors to short and/or long-term human health and diseases. Numerous studies have demonstrated that human gut microbial colonization begins at birth, but continues to develop a succession of taxonomic abundances for two to three years until the gut microbiota reaches adult-like diversity and proportions. Several factors, including gestational age (GA), delivery mode, birth weight, feeding types, antibiotic exposure, maternal microbiome, and diet, influence the diversity, abundance, and function of early life gut microbiota. Gut microbial life is essential for assisting with the digestion of food substances to release nutrients, exerting control over pathogens, stimulating or modulating the immune system, and influencing many systems such as the liver, brain, and endocrine system. Microbial metabolites play multiple roles in these interactions. Furthermore, studies provide evidence supporting that imbalances of the gut microbiota in early life, referred to as dysbiosis, are associated with specific childhood or adult disease outcomes, such as asthma, atopic dermatitis, diabetes, allergic diseases, obesity, cardiovascular diseases (CVD), and neurological disorders. These findings support that the human gut microbiota may play a fundamental role in the risk of acquiring diseases that may be programmed during early life. In fact, it is critical to explore the role of the human gut microbiota in early life.

Indexed as

Developmental Origins of Health and Disease (DOHaD)early-life gut microbiotagut dysbiosisgut microbiotalong-term health and disease

Identifiers

PMID33504109
PMCPMC7865818
OpenAlexW3107693402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.